Τίτλος:
Galectin-3 is associated with glomerular filtration rate and outcome in patients with stable decompensated cirrhosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Newly introduced galectin-3 (gal-3) has been associated to impaired renal function. Gal-3 may become prognostic biomarker in hepatic diseases. Aim: To investigate the association of gal-3 with prognosis and renal function in patients with stable decompensated cirrhosis. Method: We studied prospectively 100 stable decompensated patients in our Department between 2010 and 2017. We measured gal-3 in serum samples. Patients’ renal function was assessed using 51Chromium-EDTA (“true GFR”). Results: Seventy patients (70%) survived and 30 died (n = 16) or underwent LT (n = 14). Twenty nine patients (29%) had normal gal-3, 71 (71%) had ≥11.7 ng/mL; they differed significantly regarding mean “true”-GFR: 90 ± 20 mL/min vs. 76 ± 26 mL/min, p = 0.03 and mean creatinine: 0.83 ± 0.14 mg/dL vs. 0.97 ± 0.4 mg/dL, p = 0.05. Median gal-3 levels were 17.5 ng/mL (range 4.9–76.5 ng/mL); 49 patients with gal-3 ≥17.5 ng/mL had significantly higher MELD score, (15 ± 5 vs. 13 ± 4, p = 0.02) and worse “true” GFR (74 vs. 85 mL/min, p = 0.04). Gal-3 had good performance in predicting “true”-GFR < 60 mL/min; AUC: 0.71, 95%CI [0.58–0.85], best cut off value 17.5 ng/mL. Kaplan–Meier analysis, using median gal-3 (17.5 ng/mL) revealed different survival time for our patients (log-rank p = 0.04). Conclusion: Gal-3 proved trustworthy marker of established chronic kidney disease, with predictive ability in stable decompensated cirrhosis. Gal-3 came also a significant factor for our patients’ outcome. © 2019 Editrice Gastroenterologica Italiana S.r.l.
Συγγραφείς:
Oikonomou, T.
Goulis, I.
Ntogramatzi, F.
Athanasiadou, Z.
Vagdatli, E.
Akriviadis, E.
Cholongitas, E.
Περιοδικό:
Digestive and Liver Disease
Λέξεις-κλειδιά:
albumin; bilirubin; creatinine; edetate chromium cr 51; galectin 3; galectin 3, adult; albumin blood level; Article; bilirubin blood level; cohort analysis; controlled study; creatinine blood level; decompensated liver cirrhosis; disease marker; female; glomerulus filtration rate; human; Kaplan Meier method; kidney function; major clinical study; male; Model For End Stage Liver Disease Score; priority journal; prognosis; prospective study; protein blood level; survival time; treatment outcome; blood; chronic kidney failure; complication; deterioration; Greece; liver cirrhosis; middle aged; mortality; pathophysiology; predictive value, Clinical Deterioration; Correlation of Data; Female; Galectin 3; Glomerular Filtration Rate; Greece; Humans; Kaplan-Meier Estimate; Liver Cirrhosis; Male; Middle Aged; Predictive Value of Tests; Prognosis; Renal Insufficiency, Chronic
DOI:
10.1016/j.dld.2019.05.030
