Τίτλος:
New insights into weaning from mechanical ventilation: Left ventricular diastolic dysfunction is a key player
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To investigate the diagnostic performance of Doppler echocardiography (DE) in predicting the outcome of weaning from mechanical ventilation in patients without overt cardiac disease. Methods: Fifty critical care noncardiac patients who fulfilled predetermined criteria for weaning underwent DE before and at the end of spontaneous breathing trial (pre-SBT/end-SBT, respectively). "Conventional" mitral inflow analysis and "advanced" DE parameters [tissue Doppler imaging (TDI)-derived mitral/tricuspid annular velocities and color M-mode Doppler velocity of propagation (V p)] were used to assess left ventricular (LV) diastolic function/filling pressures. Weaning was considered successful if patients had been extubated after successful SBT and sustained spontaneous breathing for more than 48 h. Results: Twenty-eight patients (56%) failed weaning: 23 patients failed SBT and 5 required reintubation within 48 h. Weaning failure was associated with the degree of LV diastolic dysfunction at pre-SBT (P = 0.01). Patients who failed weaning presented evidence of increased LV filling pressures at pre-SBT, by demonstrating increased E/E m and E/V p ratios compared with patients with successful outcome (P ≤ 0.004); pre-SBT values of lateral E/E m greater than 7.8 and E/V p greater than 1.51 predicted weaning failure with an area under the curve, sensitivity (%), and specificity (%) of 0.86, 79, and 100, and 0.74, 75, and 73, respectively. Lateral E/E m was the only factor independently associated with weaning failure before SBT; OR (95% CI) 5.62 (1.17-26.96), P = 0.03. Conclusions: Our findings suggest that LV diastolic dysfunction is significantly associated with weaning outcome in critically ill patients with preserved LV systolic function. An E/E m ratio greater than 7.8 may identify patients at high risk of weaning failure. © 2011 Copyright jointly held by Springer and ESICM.
Συγγραφείς:
Papanikolaou, J.
Makris, D.
Saranteas, T.
Karakitsos, D.
Zintzaras, E.
Karabinis, A.
Kostopanagiotou, G.
Zakynthinos, E.
Περιοδικό:
Intensive Care Medicine Experimental
Λέξεις-κλειδιά:
adult; area under the curve; article; artificial ventilation; brain hemorrhage; clinical article; female; heart left ventricle failure; heart left ventricle filling pressure; human; male; outcome assessment; prospective study; sensitivity and specificity; tissue Doppler imaging; traumatic brain injury; adverse effects; critical illness; diagnostic imaging; Doppler echocardiography; heart left ventricle function; hemodynamics; intensive care; middle aged; pathophysiology; physiology; procedures; Respiratory Insufficiency; risk factor; statistical model; ventilator weaning, Critical Care; Critical Illness; Echocardiography, Doppler; Female; Hemodynamics; Humans; Logistic Models; Male; Middle Aged; Prospective Studies; Respiration, Artificial; Respiratory Insufficiency; Risk Factors; Ventilator Weaning; Ventricular Dysfunction, Left; Ventricular Function, Left
DOI:
10.1007/s00134-011-2368-0
