Τίτλος:
The effect of 23-valent pneumococcal polysaccharide vaccine on
immunological priming induced by 7-valent conjugate vaccine in asplenic
subjects with beta-thalassemia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The effect of the 23-valent pneumococcal polysaccharide vaccine (PPV) on
the 7-valent conjugate (PCV) vaccine-induced priming was evaluated in 35
splenectomised beta-thalassemics [median (range) age: 30 (12-41)
years] vaccinated with either PCV/PPV or two PCVs 1 month apart,
followed by a PPV booster 12 months later. 28/35 had already received
1-3 PPVs in the past. Different schedules induced similar anamnestic
responses; however priming for 3/5 serotypes induced by one or two PCVs,
was inferior in subjects who had received >= 2 PPVs in the past when
compared with 23 aged-matched PPV-naive beta-thalassemics. One PPV
following PCV does not affect PCV priming; multiple PPVs induce
hyporesponsiveness for some serotypes in splenectomised subjects with
beta-thalassemia. (C) 2008 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Orthopoulos, George V.
Theodoridou, Maria C.
Ladis, Vasilis A.
and Tsousis, Dimitris K.
Spoulou, Vana I.
Εκδότης:
Elsevier Sci Ltd, Exeter, United Kingdom
Λέξεις-κλειδιά:
Pneumococcal vaccine; Hyporesponsiveness; beta-Thalassemia
DOI:
10.1016/j.vaccine.2008.10.070
