Περίληψη:
Background: A potential dual role of folate in colorectal cancer (CRC)
is currently subject to debate. We investigate the associations between
plasma folate, several relevant folate-related polymorphisms, and CRC
risk within the large European Prospective Investigation into Cancer and
Nutrition cohort.
Methods: In this nested case-control study, 1,367 incident CRC cases
were matched to 2,325 controls for study center, age, and sex. Risk
ratios (RR) were estimated with conditional logistic regression and
adjusted for smoking, education, physical activity, and intake of
alcohol and fiber.
Results: Overall analyses did not reveal associations of plasma folate
with CRC. The RR (95% confidence interval; P-trend) for the fifth
versus the first quintile of folate status was 0.94 (0.74-1.20; 0.44).
The polymorphisms MTHFR677C -> T, MTHFR1298A -> C, MTR2756A -> G,
MTRR66A -> G, and MTHFD11958G -> A were not associated with CRC risk.
However, in individuals with the lowest plasma folate concentrations,
the MTHFR 677TT genotype showed a statistically nonsignificant increased
CRC risk [RR (95% CI; P-trend) TT versus CC = 1.39 (0.87-2.21);
0.12], whereas those with the highest folate concentrations showed a
nonsignificant decreased CRC risk [RR TT versus CC = 0.74 (0.39-1.37);
0.34]. The SLC19A180G -> A showed a positive association with CRC risk
[RR AA versus GG 1.30 (1.06-1.59); <0.01].
Conclusions: This large European prospective multicenter study did not
show an association of CRC risk with plasma folate status nor with MTHFR
polymorphisms.
Impact: Findings of the present study tend to weaken the evidence that
folate plays an important role in CRC carcinogenesis. However, larger
sample sizes are needed to adequately address potential gene-environment
interactions. Cancer Epidemiol Biomarkers Prev; 19(5); 1328-40. (C)2010
AACR.
Συγγραφείς:
Eussen, Simone J. P. M.
Vollset, Stein Emil
Igland, Jannicke and
Meyer, Klaus
Fredriksen, Ase
Ueland, Per Magne
Jenab, Mazda
and Slimani, Nadia
Boffetta, Paolo
Overvad, Kim
Tjonneland,
Anne
Olsen, Anja
Clavel-Chapelon, Francoise
Boutron-Ruault,
Marie-Christine
Morois, Sophie
Weikert, Cornelia
Pischon,
Tobias
Linseisen, Jakob
Kaaks, Rudolf
Trichopoulou, Antonia
and Zilis, Demosthenes
Katsoulis, Michael
Palli, Domenico and
Berrino, Franco
Vineis, Paolo
Tumino, Rosario
Panico,
Salvatore
Peeters, Petra H. M.
Bueno-de-Mesquita, H. Bas
van
Duijnhoven, Franzel J. B.
Gram, Inger Torhild
Skeie, Guri and
Lund, Eiliv
Gonzalez, Carlos A.
Martinez, Carmen
Dorronsoro,
Miren
Ardanaz, Eva
Navarro, Carmen
Rodriguez, Laudina and
Van Guelpen, Bethany
Palmqvist, Richard
Manjer, Jonas and
Ericson, Ulrika
Bingham, Sheila
Khaw, Kay-Tee
Norat, Teresa
and Riboli, Elio
