Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Effects of Prolonged Warm and Cold Ischemia in a Solitary Kidney Animal
Model after Partial Nephrectomy: An Ultrastructural Investigation
Model after Partial Nephrectomy: An Ultrastructural Investigation
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Ischemia–reperfusion injury can be detrimental to the solitary kidney,
especially when it is accompanied by ablation. To the authors”
knowledge, the effects of partial nephrectomy with prolonged application
of ischemia have never been described at the ultrastructural level.
Therefore, the authors used an animal model and focused on putative
structural effects in the glomerular basement membrane and the
podocytes. They demonstrate the advantageous role of cold ischemia, even
in up to 120 min. In contrast, more than 60 min of warm ischemia leads
to catastrophic lesions in all the cellular structures, as is reflected
by mortality due to acute renal failure.
especially when it is accompanied by ablation. To the authors”
knowledge, the effects of partial nephrectomy with prolonged application
of ischemia have never been described at the ultrastructural level.
Therefore, the authors used an animal model and focused on putative
structural effects in the glomerular basement membrane and the
podocytes. They demonstrate the advantageous role of cold ischemia, even
in up to 120 min. In contrast, more than 60 min of warm ischemia leads
to catastrophic lesions in all the cellular structures, as is reflected
by mortality due to acute renal failure.
Έτος δημοσίευσης:
2011
Συγγραφείς:
Tyritzis, Stavros I.
Zachariades, Michael
Evangelou, Kostas and
Gorgoulis, Vassilis G.
Kyroudi-Voulgari, Aspasia
Pavlakis, Kitty
and Troupis, Theodoros G.
Constantinides, Constantinos A.
Zachariades, Michael
Evangelou, Kostas and
Gorgoulis, Vassilis G.
Kyroudi-Voulgari, Aspasia
Pavlakis, Kitty
and Troupis, Theodoros G.
Constantinides, Constantinos A.
Περιοδικό:
Ultrastructural Pathology
Εκδότης:
Taylor and Francis Inc.
Τόμος:
35
Αριθμός / τεύχος:
2
Σελίδες:
60-65
Λέξεις-κλειδιά:
Electron microscopy; Ischemia-reperfusion injury; Partial nephrectomy;
Rabbit; Solitary kidney
Rabbit; Solitary kidney
Επίσημο URL (Εκδότης):
DOI:
10.3109/01913123.2010.542880
Μόνιμη διεύθυνση:
Το ψηφιακό υλικό του τεκμηρίου δεν είναι διαθέσιμο.
