Περίληψη:
Background: A moderate association exists between body mass index (BMI)
and colorectal cancer. Less is known about the effect of weight change.
Objective: We investigated the relation between BMI and weight change
and subsequent colon and rectal cancer risk.
Design: This was studied among 328,781 participants in the prospective
European Prospective Investigation into Cancer Physical Activity,
Nutrition, Alcohol, Cessation of Smoking, Eating study (mean age: 50 y).
Body weight was assessed at recruitment and on average 5 y later.
Self-reported weight change (kg/y) was categorized in sex-specific
quintiles, with quintiles 2 and 3 combined as the reference category
(men: -0.6 to 0.3 kg/y; women: -0.4 to 0.4 kg/y). In the subsequent
years, participants were followed for the occurrence of colon and rectal
cancer (median period: 6.8 y). Multivariable Cox proportional hazards
regression analyses were used to study the association.
Results: A total of 1261 incident colon cancer and 747 rectal cancer
cases were identified. ME at recruitment was statistically significantly
associated with colon cancer risk in men (HR: 1.04; 95% CI: 1.02,
1.07). Moderate weight gain (quintile 4) in men increased risk further
(HR: 1.32; 95% CI: 1.04, 1.68), but this relation did not show a clear
trend. In women, BMI or weight gain was not related to subsequent risk
of colon cancer. No statistically significant associations for weight
loss and colon cancer or for BMI and weight changes and rectal cancer
were found.
Conclusions: BMI attained at adulthood was associated with colon cancer
risk. Subsequent weight gain or loss was not related to colon or rectal
cancer risk in men or women.
Συγγραφείς:
Bisschop, Charlotte N. Steins
van Gils, Carla H.
Emaus, Marleen
J.
Bueno-de-Mesquita, H. Bas
Monninkhof, Evelyn M.
Boeing,
Heiner
Aleksandrova, Krasmira
Jenab, Mazda
Norat, Teresa and
Riboli, Elio
Boutron-Ruault, Marie-Christine
Fagherazzi, Guy and
Racine, Antoine
Palli, Domenico
Krogh, Vittorio
Tumino,
Rosario
Naccarati, Alessio
Mattiello, Amalia
Vicente
Argueeles, Marcial
Jose Sanchez, Maria
Jose Tormo, Maria and
Ardanaz, Eva
Dorronsoro, Miren
Bonet, Catalina
Khaw, Kay-Tee
and Key, Tim
Trichopoulou, Antonia
Orfanos, Philippos
Naska,
Androniki
Kaaks, Rudolph R.
Lukanova, Annekatrin
Pischon,
Tobias
Ljuslinder, Ingrid
Jirstrom, Karin
Ohlsson, Bodil and
Overvad, Kim
Berentzen, Tina Landsvig
Halkjaer, Jytte and
Tjonneland, Anne
Weiderpass, Elisabete
Skeie, Guri
Braaten,
Tonje
Siersema, Peter D.
Freisling, Heinz
Ferrari, Pietro
and Peeters, Petra H. M.
May, Anne M.
