Περίληψη:
Previous epidemiological studies suggest an inverse association between
allergies, marked by elevated immunoglobulin (Ig) E levels, and
non-Hodgkin lymphoma (NHL) risk. The evidence, however, is inconsistent
and prospective data are sparse. We examined the association between
prediagnostic total (low: < 20; intermediate: 20-100; high > 100 kU/l)
and specific IgE (negative: < 0.35; positive >= 0.35 kU/I)
concentrations against inhalant antigens and lymphoma risk in a study
nested within the European Prospective Investigation into Cancer and
Nutrition cohort. A total of 1021 incident cases and matched controls of
NHL, multiple myeloma (MM) and Hodgkin lymphoma with a mean follow-up
time of 7 years were investigated. Multivariate-adjusted odds ratios
(ORs) with 95% confidence intervals (CI) were calculated by conditional
logistic regression. Specific IgE was not associated with the risk of
MM, B-cell NHL and B-cell NHL subtypes. In contrast, total IgE levels
were inversely associated with the risk of MM [high level: OR = 0.40
(95% CI = 0.21-0.79)] and B-cell NHL [intermediate level: OR = 0.68
(95% CI = 0.53-0.88); high level: OR = 0.62 (95% CI = 0.44-0.86)],
largely on the basis of a strong inverse association with chronic
lymphocytic leukemia [CLL; intermediate level: OR = 0.49 (95% CI =
0.30-0.80); high level: OR = 0.13 (95% CI = 0.05-0.35)] risk. The
inverse relationship for CLL remained significant for those diagnosed 5
years after baseline. The findings of this large prospective study
demonstrated significantly lower prediagnostic total IgE levels among
CLL and MM cases compared with matched controls. This corresponds to the
clinical immunodeficiency state often observed in CLL patients prior to
diagnosis. No support for an inverse association between prediagnostic
levels of specific IgE and NHL risk was found.
Συγγραφείς:
Nieters, Alexandra
Luczynska, Anna
Becker, Susen
Becker,
Nikolaus
Vermeulen, Roel
Overvad, Kim
Aleksandrova,
Krasimira
Boeing, Heiner
Lagiou, Pagona
Trichopoulos,
Dimitrios
Trichopoulou, Antonia
Krogh, Vittorio
Masala,
Giovanna
Panico, Salvatore
Tumino, Rosario
Sacerdote,
Carlotta
Bueno-de-Mesquita, Bas
Jeurnink, Suzanne M. and
Weiderpass, Elisabete
Ardanaz, Eva
Chirlaque, Maria-Dolores and
Sanchez, Maraia-Jose
Sanchez, Soledad
Borgquist, Signe
Butt,
Salma
Melin, Beatrice
Spaeth, Florentin
Rinaldi, Sabina and
Brennan, Paul
Kelly, Rachel S.
Riboli, Elio
Vineis, Paolo
and Kaaks, Rudolf
