Τίτλος:
Expression of estrogen receptors in non-malignant mammary tissue
modifies the association between insulin-like growth factor 1 and breast
cancer risk
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Several studies have reported that the insulin-like growth
factor 1 (IGF-1) is positively associated with estrogen
receptor-positive [ER(+)] breast cancer risk, whereas there is little
or no association with respect to ER(-) breast cancer. All comparisons
of ER(+) breast cancer cases, however, have been made versus healthy
controls, for whom there is no information about the ER expression in
their mammary gland.
Patients and methods: In the context of a case-control investigation
conducted in Athens, Greece, we studied 102 women with incident ER
alpha(+) breast cancer and compared their IGF-1 blood levels with those
of 178 ER alpha(+) and 83 ER alpha(-) women with benign breast disease
(BBD) who underwent biopsies in the context of their standard medical
care. Data were analysed using multiple logistic regression and
controlling for potential confounding variables.
Results: ER alpha(+) breast cancer patients had higher IGF-1 levels
compared with women with BBD [odds ratio (OR) 1.36, 95% confidence
interval (CI): 0.95-1.94, per 1 standard deviation (SD) increase in
IGF-1 levels]. When ER alpha status of women with BBD was taken into
account, the difference in IGF-1 levels between ER alpha(+) breast
cancer patients and women with BBD was clearly driven by the comparison
with BBD women who were ER alpha(+) (OR = 1.95, 95% CI: 1.31-2.89 per 1
SD increase in IGF-1 levels), whereas there was essentially no
association with IGF-1 levels when ER alpha(+) breast cancer patients
were compared with ER alpha(-) BBD women. These contrasts were
particularly evident among post/peri-menopausal women.
Conclusion(s): We found evidence in support of an interaction of IGF-1
with the expression of ER alpha in the non-malignant mammary tissue in
the context of breast cancer pathogenesis. This is in line with previous
evidence suggesting that IGF-1 increases the risk of ER(+) breast
cancer.
Συγγραφείς:
Samoli, E.
Lagiou, A.
Zourna, P.
Barbouni, A.
Georgila,
C.
Tsikkinis, A.
Vassilarou, D.
Minaki, P.
Sfikas, C.
and Spanos, E.
Trichopoulos, D.
Lagiou, P.
Περιοδικό:
Annals of Oncology
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
benign breast disease; BBD; breast cancer; epidemiology; IGF-1
DOI:
10.1093/annonc/mdu583
