Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3174981 67 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Identification of 12 new susceptibility loci for different histotypes of
epithelial ovarian cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
To identify common alleles associated with different histotypes of
epithelial ovarian cancer (EOC), we pooled data from multiple
genome-wide genotyping projects totaling 25,509 EOC cases and 40,941
controls. We identified nine new susceptibility loci for different EOC
histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11,
10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1)
and one for endometrioid EOC (5q12.3). We then performed meta-analysis
on the results for high-grade serous ovarian cancer with the results
from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including
3,887 mutation carriers with EOC. This identified three additional
susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of
genes and regulatory biofeatures at each locus predicted candidate
susceptibility genes, including OBFC1, a new candidate susceptibility
gene for low-grade and borderline serous EOC.
Έτος δημοσίευσης:
2017
Συγγραφείς:
Phelan, Catherine M.
Kuchenbaecker, Karoline B.
Tyrer, Jonathan
P.
Kar, Siddhartha P.
Lawrenson, Kate
Winham, Stacey J. and
Dennis, Joe
Pirie, Ailith
Riggan, Marjorie J.
Chornokur,
Ganna
Earp, Madalene A.
Lyra, Jr., Paulo C.
Lee, Janet M.
and Coetzee, Simon
Beesley, Jonathan
McGuffog, Lesley
Soucy,
Penny
Dicks, Ed
Lee, Andrew
Barrowdale, Daniel and
Lecarpentier, Julie
Leslie, Goska
Aalfs, Cora M.
Aben, Katja
K. H.
Adams, Marcia
Adlard, Julian
Andrulis, Irene L. and
Anton-Culver, Hoda
Antonenkova, Natalia
Aravantinos, Gerasimos
and Arnold, Norbert
Arun, Banu K.
Arver, Brita
Azzollini,
Jacopo
Balmana, Judith
Banerjee, Susana N.
Barjhoux, Laure
and Barkardottir, Rosa B.
Bean, Yukie
Beckmann, Matthias W. and
Beeghly-Fadiel, Alicia
Benitez, Javier
Bermisheva, Marina and
Bernardini, Marcus Q.
Birrer, Michael J.
Bjorge, Line
Black,
Amanda
Blankstein, Kenneth
Blok, Marinus J.
Bodelon, Clara
and Bogdanova, Natalia
Bojesen, Anders
Bonanni, Bernardo and
Borg, Ake
Bradbury, Angela R.
Brenton, James D.
Brewer,
Carole
Brinton, Louise
Broberg, Per
Brooks-Wilson, Angela
and Bruinsma, Fiona
Brunet, Joan
Buecher, Bruno
Butzow, Ralf
and Buys, Saundra S.
Caldes, Trinidad
Caligo, Maria A. and
Campbell, Ian
Cannioto, Rikki
Carney, Michael E.
Cescon,
Terence
Chan, Salina B.
Chang-Claude, Jenny
Chanock, Stephen
and Chen, Xiao Qing
Chiew, Yoke-Eng
Chiquette, Jocelyne and
Chung, Wendy K.
Claes, Kathleen B. M.
Conner, Thomas
Cook,
Linda S.
Cook, Jackie
Cramer, Daniel W.
Cunningham, Julie M.
and D'Aloisio, Aimee A.
Daly, Mary B.
Damiola, Francesca and
Damirovna, Sakaeva Dina
Dansonka-Mieszkowska, Agnieszka
Dao,
Fanny
Davidson, Rosemarie
DeFazio, Anna
Delnatte, Capucine
and Doheny, Kimberly F.
Diez, Orland
Ding, Yuan Chun and
Doherty, Jennifer Anne
Domchek, Susan M.
Dorfling, Cecilia M.
and Dork, Thilo
Dossus, Laure
Duran, Mercedes
Durst,
Matthias
Dworniczak, Bernd
Eccles, Diana
Edwards, Todd and
Eeles, Ros
Eilber, Ursula
Ejlertsen, Bent
Ekici, Arif B. and
Ellis, Steve
Elvira, Mingajeva
Eng, Kevin H.
Engel,
Christoph
Evans, D. Gareth
Fasching, Peter A.
Ferguson,
Sarah
Ferrer, Sandra Fert
Flanagan, James M.
Fogarty,
Zachary C.
Fortner, Renee T.
Fostira, Florentia
Foulkes,
William D.
Fountzilas, George
Fridley, Brooke L.
Friebel,
Tara M.
Friedman, Eitan
Frost, Debra
Ganz, Patricia A. and
Garber, Judy
Garcia, Maria J.
Garcia-Barberan, Vanesa and
Gehrig, Andrea
Gentry-Maharaj, Aleksandra
Gerdes, Anne-Marie and
Giles, Graham G.
Glasspool, Rosalind
Glendon, Gord
Godwin,
Andrew K.
Goldgar, David E.
Goranova, Teodora
Gore, Martin
and Greene, Mark H.
Gronwald, Jacek
Gruber, Stephen
Hahnen,
Eric
Haiman, Christopher A.
Hakansson, Niclas
Hamann, Ute
and Hansen, Thomas V. O.
Harrington, Patricia A.
Harris, Holly
R.
Hauke, Jan
Hein, Alexander
Henderson, Alex and
Hildebrandt, Michelle A. T.
Hillemanns, Peter
Hodgson, Shirley
and Hogdall, Claus K.
Hogdall, Estrid
Hogervorst, Frans B. L.
and Holland, Helene
Hooning, Maartje J.
Hosking, Karen and
Huang, Ruea-Yea
Hulick, Peter J.
Hung, Jillian
Hunter, David
J.
Huntsman, David G.
Huzarski, Tomasz
Imyanitov, Evgeny N.
and Isaacs, Claudine
Iversen, Edwin S.
Izatt, Louise and
Izquierdo, Angel
Jakubowska, Anna
James, Paul
Janavicius,
Ramunas
Jernetz, Mats
Jensen, Allan
Jensen, Uffe Birk and
John, Esther M.
Johnatty, Sharon
Jones, Michael E.
Kannisto,
Paivi
Karlan, Beth Y.
Karnezis, Anthony
Kast, Karin and
Kennedy, Catherine J.
Khusnutdinova, Elza
Kiemeney, Lambertus A.
and Kiiski, Johanna I.
Kim, Sung-Won
Kjaer, Susanne K. and
Kobel, Martin
Kopperud, Reidun K.
Kruse, Torben A. and
Kupryjanczyk, Jolanta
Kwong, Ava
Laitman, Yael
Lambrechts,
Diether
Larranaga, Nerea
Larson, Melissa C.
Lazaro, Conxi
and Le, Nhu D.
Le Marchand, Loic
Lee, Jong Won
Lele,
Shashikant B.
Leminen, Arto
Leroux, Dominique
Lester, Jenny
and Lesueur, Fabienne
Levine, Douglas A.
Liang, Dong and
Liebrich, Clemens
Lilyquist, Jenna
Lipworth, Loren and
Lissowska, Jolanta
Lu, Karen H.
Lubinski, Jan
Luccarini,
Craig
Lundvall, Lene
Mai, Phuong L.
Mendoza-Fandino, Gustavo
and Manoukian, Siranoush
Massuger, Leon F. A. G.
May, Taymaa and
Mazoyer, Sylvie
McAlpine, Jessica N.
McGuire, Valerie and
McLaughlin, John R.
McNeish, Iain
Meijers-Heijboer, Hanne and
Meindl, Alfons
Menon, Usha
Mensenkamp, Arjen R.
Merritt,
Melissa A.
Milne, Roger L.
Mitchell, Gillian
Modugno,
Francesmary
Moes-Sosnowska, Joanna
Moffitt, Melissa and
Montagna, Marco
Moysich, Kirsten B.
Mulligan, Anna Marie and
Musinsky, Jacob
Nathanson, Katherine L.
Nedergaard, Lotte and
Ness, Roberta B.
Neuhausen, Susan L.
Nevanlinna, Heli and
Niederacher, Dieter
Nussbaum, Robert L.
Odunsi, Kunle
Olah,
Edith
Olopade, Olufunmilayo I.
Olsson, Hakan
Olswold, Curtis
and O'Malley, David M.
Ong, Kai-ren
Onland-Moret, N. Charlotte
and Orr, Nicholas
Orsulic, Sandra
Osorio, Ana
Palli,
Domenico
Papi, Laura
Park-Simon, Tjoung-Won
Paul, James and
Pearce, Celeste L.
Pedersen, Inge Sokilde
Peeters, Petra H. M.
and Peissel, Bernard
Peixoto, Ana
Pejovic, Tanja
Pelttari,
Liisa M.
Permuth, Jennifer B.
Peterlongo, Paolo
Pezzani,
Lidia
Pfeiler, Georg
Phillips, Kelly-Anne
Piedmonte, Marion
and Pike, Malcolm C.
Piskorz, Anna M.
Poblete, Samantha R. and
Pocza, Timea
Poole, Elizabeth M.
Poppe, Bruce
Porteous, Mary
E.
Prieur, Fabienne
Prokofyeva, Darya
Pugh, Elizabeth and
Pujana, Miquel Angel
Pujol, Pascal
Radice, Paolo
Rantala,
Johanna
Rappaport-Fuerhauser, Christine
Rennert, Gad
Rhiem,
Kerstin
Rice, Patricia
Richardson, Andrea
Robson, Mark and
Rodriguez, Gustavo C.
Rodriguez-Antona, Cristina
Romm, Jane and
Rookus, Matti A.
Rossing, Mary Anne
Rothstein, Joseph H. and
Rudolph, Anja
Runnebaum, Ingo B.
Salvesen, Helga B.
Sandler,
Dale P.
Schoemaker, Minouk J.
Senter, Leigha
Setiawan, V.
Wendy
Severi, Gianluca
Sharma, Priyanka
Shelford, Tameka and
Siddiqui, Nadeem
Side, Lucy E.
Sieh, Weiva
Singer, Christian
F.
Sobol, Hagay
Song, Honglin
Southey, Melissa C. and
Spurdle, Amanda B.
Stadler, Zsofia
Steinemann, Doris and
Stoppa-Lyonnet, Dominique
Sucheston-Campbell, Lara E. and
Sukiennicki, Grzegorz
Sutphen, Rebecca
Sutter, Christian and
Swerdlow, Anthony J.
Szabo, Csilla I.
Szafron, Lukasz
Tan,
Yen Y.
Taylor, Jack A.
Tea, Muy-Kheng
Teixeira, Manuel R.
and Teo, Soo-Hwang
Terry, Kathryn L.
Thompson, Pamela J. and
Thomsen, Liv Cecilie Vestrheim
Thull, Darcy L.
Tihomirova, Laima
and Tinker, Anna V.
Tischkowitz, Marc
Tognazzo, Silvia and
Toland, Amanda Ewart
Tone, Alicia
Trabert, Britton
Travis,
Ruth C.
Trichopoulou, Antonia
Tung, Nadine
Tworoger, Shelley
S.
Van Altena, Anne M.
Van den Berg, David
van der Hout,
Annemarie H.
van der Luijt, Rob B.
Van Heetvelde, Mattias and
Van Nieuwenhuysen, Els
Van Rensburg, Elizabeth J. and
Vanderstichele, Adriaan
Varon-Mateeva, Raymonda
Vega, Ana and
Edwards, Digna Velez
Vergote, Ignace
Vierkant, Robert A. and
Vijai, Joseph
Vratimos, Athanassios
Walker, Lisa
Walsh,
Christine
Wand, Dorothea
Wang-Gohrke, Shan
Wappenschmidt,
Barbara
Webb, Penelope M.
Weinberg, Clarice R.
Weitzel,
Jeffrey N.
Wentzensen, Nicolas
Whittemore, Alice S.
Wijnen,
Juul T.
Wilkens, Lynne R.
Wolk, Alicja
Woo, Michelle
Wu,
Xifeng
Wu, Anna H.
Yang, Hannah
Yannoukakos, Drakoulis and
Ziogas, Argyrios
Zorn, Kristin K.
Narod, Steven A.
Easton,
Douglas F.
Amos, Christopher I.
Schildkraut, Joellen M. and
Ramus, Susan J.
Ottini, Laura
Goodman, Marc T.
Park-, Sue K.
and Kelemen, Linda E.
Risch, Harvey A.
Thomassen, Mads and
Offit, Kenneth
Simard, Jacques
Schmutzler, Rita Katharina and
Hazelett, Dennis
Monteiro, Alvaro N.
Couch, Fergus J. and
Berchuck, Andrew
Chenevix-Trench, Georgia
Goode, Ellen L. and
Sellers, Thomas A.
Gayther, Simon A.
Antoniou, Antonis C. and
Pharoah, Paul D. P.
AOCS Study Grp
EMEMBRACE Study
GEMO
Study Collaborators
HEBON Study
KConFab Investigators
OPAL
Study Grp
Περιοδικό:
Nature Genetics
Εκδότης:
Nature Publishing Group
Τόμος:
49
Αριθμός / τεύχος:
5
Σελίδες:
680-691
Επίσημο URL (Εκδότης):
DOI:
10.1038/ng.3826
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