Τίτλος:
Effectiveness of quadrivalent influenza vaccine in pregnant women and infants, 2018–2019
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Influenza is associated with an increased risk for serious illness, hospitalization and/or death in pregnant women and young infants. We prospectively studied the effectiveness of a quadrivalent inactivated influenza vaccine (QIV) in pregnant women and their infants during the 2018–2019 influenza season. A QIV was offered to pregnant women cared in a maternity hospital in Athens. Women were contacted weekly by telephone during the influenza season and PCR test was offered to women or infants who developed influenza-like illness (ILI). We studied 423 pregnant women and 446 infants. Unvaccinated pregnant women had a 7.5% probability to develop laboratory-confirmed influenza compared to 2.1% among vaccinated women (Odds ratio: 3.6; confidence intervals: 1.14–11.34, p-value = 0.029). Infants whose mothers were not vaccinated had a 7.9% probability to develop laboratory-confirmed influenza compared to 2.8% among infants of vaccinated mothers (Odds ratio = 2.849, confidence intervals: 0.892–9.102, p-value = 0.053). Cox regression analyses showed that QIV vaccination was significantly associated with a decreased probability for laboratory-confirmed influenza, ILI, healthcare seeking and hospitalization among pregnant women and a decreased probability for laboratory-confirmed influenza, healthcare seeking and prescription of antibiotics among infants. The effectiveness of QIV against laboratory-confirmed influenza was 72% among pregnant women and 64.5% among infants during the 2018–2019 influenza season. Vaccination of pregnant women with the QIV was associated with a lower risk for laboratory-confirmed influenza for them and their infants during the influenza season. Our findings strongly support the World Health Organization recommendations for vaccinating pregnant women against influenza. © 2020 Elsevier Ltd
Συγγραφείς:
Maltezou, H.C.
Asimakopoulos, G.
Stavrou, S.
Daskalakis, G.
Koutroumanis, P.
Sindos, M.
Theodora, M.
Katerelos, P.
Kostis, E.
Gavrili, S.
Kossyvakis, A.
Theodoridou, M.
Mentis, A.
Drakakis, P.
Loutradis, D.
Rodolakis, A.
Εκδότης:
ELSEVIER SCIENCE LTD.
Λέξεις-κλειδιά:
antibiotic agent; antivirus agent; influenza vaccine; influenza vaccine, adult; Article; child; cohort analysis; controlled study; drug efficacy; female; flu like syndrome; Greece; help seeking behavior; hospitalization; human; infant; influenza; influenza vaccination; low risk population; major clinical study; observational study; odds ratio; polymerase chain reaction; practice guideline; pregnant woman; prescription; priority journal; probability; World Health Organization; influenza; pregnancy; pregnancy complication; pregnant woman; vaccination, Female; Humans; Infant; Influenza Vaccines; Influenza, Human; Pregnancy; Pregnancy Complications, Infectious; Pregnant Women; Vaccination
DOI:
10.1016/j.vaccine.2020.04.060
