Περίληψη:
Objective: Data regarding the potential association between the outcome of psychotherapy of panic disorder (PD) and biological parameters are few. In 21 (16 females) consecutively referred, medication-free, acutely ill PD outpatients, without comorbidities, except agoraphobia, we systematically explored for potential neuroendocrine and clinical correlates of response to a brief cognitive behavior therapy (CBT). Methods: Cortisol and adrenocorticotropic hormone (ACTH) basal plasma levels were measured. Measures of psychopathology: (a) Symptom Checklist-90-Revised (SCL-90-R), (b) Clinical Global Impressions-Improvement (CGI-I) Scale, (c) Agoraphobic Cognitions Questionnaire (ACQ), and (d) Mobility Inventory (MI)-alone subscale. Results: Nonresponders to CBT (CGI-I >2; N = 6) - as compared to the responders (CGI-I ≤2; N = 15) - demonstrated significantly higher cortisol and ACTH basal plasma concentrations. These differences were much stronger when only female patients (nonresponders = 4; responders = 12) were taken into consideration. Regarding psychopathology, nonresponders to CBT suffered from more severe agoraphobia (MI-alone) at baseline. On the contrary, more intense manifestations of anger (SCL-90-R) at baseline were associated with a better treatment outcome. Response to CBT was associated with significant reductions in all SCL-90-R subscales, more pronounced for "phobic anxiety"and "anxiety"subscales. Conclusions: This study suggests that in acutely ill, medication-free PD patients, response to CBT may be associated with certain hormonal and clinical parameters at baseline. © 2021
Συγγραφείς:
Masdrakis, V.G.
Legaki, E.-M.
Papageorgiou, C.
Markianos, M.
Λέξεις-κλειδιά:
corticotropin; hydrocortisone; stress hormone; corticotropin, adult; agoraphobia; Agoraphobic Cognitions Questionnaire; anger; anxiety assessment; Article; clinical article; Clinical Global Impression scale; cognitive behavioral therapy; controlled study; corticotropin blood level; disease severity; female; functional status assessment; human; hydrocortisone blood level; male; Mobility Inventory alone subscale; outpatient; panic; predictor variable; sex difference; Symptom Checklist 90-Revised; treatment outcome; treatment response; agoraphobia; anxiety disorder, Adrenocorticotropic Hormone; Agoraphobia; Anxiety Disorders; Cognitive Behavioral Therapy; Female; Humans; Panic Disorder; Treatment Outcome
