Περίληψη:
Objectives: Validated diagnostic interviews are required to classify depression status and estimate prevalence of disorder, but screening tools are often used instead. We used individual participant data meta-analysis to compare prevalence based on standard Hospital Anxiety and Depression Scale – depression subscale (HADS-D) cutoffs of ≥8 and ≥11 versus Structured Clinical Interview for DSM (SCID) major depression and determined if an alternative HADS-D cutoff could more accurately estimate prevalence. Methods: We searched Medline, Medline In-Process & Other Non-Indexed Citations via Ovid, PsycINFO, and Web of Science (inception-July 11, 2016) for studies comparing HADS-D scores to SCID major depression status. Pooled prevalence and pooled differences in prevalence for HADS-D cutoffs versus SCID major depression were estimated. Results: 6005 participants (689 SCID major depression cases) from 41 primary studies were included. Pooled prevalence was 24.5% (95% Confidence Interval (CI): 20.5%, 29.0%) for HADS-D ≥8, 10.7% (95% CI: 8.3%, 13.8%) for HADS-D ≥11, and 11.6% (95% CI: 9.2%, 14.6%) for SCID major depression. HADS-D ≥11 was closest to SCID major depression prevalence, but the 95% prediction interval for the difference that could be expected for HADS-D ≥11 versus SCID in a new study was −21.1% to 19.5%. Conclusions: HADS-D ≥8 substantially overestimates depression prevalence. Of all possible cutoff thresholds, HADS-D ≥11 was closest to the SCID, but there was substantial heterogeneity in the difference between HADS-D ≥11 and SCID-based estimates. HADS-D should not be used as a substitute for a validated diagnostic interview. © 2020 Elsevier Inc.
Συγγραφείς:
Brehaut, E.
Neupane, D.
Levis, B.
Wu, Y.
Sun, Y.
Krishnan, A.
He, C.
Bhandari, P.M.
Negeri, Z.
Riehm, K.E.
Rice, D.B.
Azar, M.
Yan, X.W.
Imran, M.
Chiovitti, M.J.
Saadat, N.
Cuijpers, P.
Ioannidis, J.P.A.
Markham, S.
Patten, S.B.
Ziegelstein, R.C.
Henry, M.
Ismail, Z.
Loiselle, C.G.
Mitchell, N.D.
Tonelli, M.
Boruff, J.T.
Kloda, L.A.
Beraldi, A.
Braeken, A.P.B.M.
Carter, G.
Clover, K.
Conroy, R.M.
Cukor, D.
da Rocha e Silva, C.E.
De Souza, J.
Downing, M.G.
Feinstein, A.
Ferentinos, P.P.
Fischer, F.H.
Flint, A.J.
Fujimori, M.
Gallagher, P.
Goebel, S.
Jetté, N.
Julião, M.
Keller, M.
Kjærgaard, M.
Love, A.W.
Löwe, B.
Martin-Santos, R.
Michopoulos, I.
Navines, R.
O'Rourke, S.J.
Öztürk, A.
Pintor, L.
Ponsford, J.L.
Rooney, A.G.
Sánchez-González, R.
Schwarzbold, M.L.
Sharpe, M.
Simard, S.
Singer, S.
Stone, J.
Tung, K.-Y.
Turner, A.
Walker, J.
Walterfang, M.
White, J.
Benedetti, A.
Thombs, B.D.
