Τίτλος:
Osteonecrosis of the jaw in oncology patients treated with bisphosphonates: Prospective experience of a dental oncology referral center
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: The objectives of this study were to define the incidence, pain, and healing in cancer patients treated with intravenous bisphosphonates. Study design: The study included long-term follow-up of 99 bisphosphonate-using patients (group A) and conservative treatment of 67 patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ, group B) using 3 antibiotic schemes and oral hygiene. Results: The frequency of zoledronic acid single-agent use was 85.9% and 69.8% in group A and B, respectively. Median follow-up was 13 months (group A) and 16 months (group B). Two patients in group A developed BRONJ (2%). Of those with BRONJ in group B who completed follow-up, healing occurred in 14.9% (7/47) and pain subsided in 80.9% (38/47). Healing was significant in patients who received pamidronate followed by zoledronic acid (P =.023) and with BRONJ stages 0 and stage I (P =.003). Conclusions: This case series suggests that oral hygiene and conservative antibiotic therapy play a role in healing and pain alleviation in BRONJ. Oral hygiene and follow-up may decrease incidence of BRONJ. © 2011 Mosby, Inc. All rights reserved.
Συγγραφείς:
Nicolatou-Galitis, O.
Papadopoulou, E.
Sarri, T.
Boziari, P.
Karayianni, A.
Kyrtsonis, M.-C.
Repousis, P.
Barbounis, V.
Migliorati, C.A.
Περιοδικό:
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Λέξεις-κλειδιά:
anticaries agent; antiinfective agent; bisphosphonic acid derivative; bone density conservation agent; chlorhexidine; fluoride; imidazole derivative; pamidronic acid; topical antiinfective agent; zoledronic acid, adult; aged; article; bone necrosis; chemically induced disorder; female; follow up; human; intravenous drug administration; jaw disease; longitudinal study; male; middle aged; mouth hygiene; neoplasm; pain assessment; preventive dentistry; prospective study; treatment outcome, Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bone Density Conservation Agents; Cariostatic Agents; Chlorhexidine; Dental Prophylaxis; Diphosphonates; Female; Fluorides; Follow-Up Studies; Humans; Imidazoles; Injections, Intravenous; Jaw Diseases; Longitudinal Studies; Male; Middle Aged; Neoplasms; Oral Hygiene; Osteonecrosis; Pain Measurement; Prospective Studies; Treatment Outcome
DOI:
10.1016/j.tripleo.2011.02.037
