Τίτλος:
Mesocorticolimbic monoamines in a rodent model of chronic neuropathic pain
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Chronic pain manifests in multiple disorders and is highly debilitating. While its pathophysiology is not fully understood, the involvement of the mesocorticolimbic monoaminergic systems have been shown to play a critical role in chronic pain emergence and/or maintenance. In this study, we analyzed the levels of monoamines dopamine (DA), noradrenaline (NA) and serotonin (5-HT) in mesocorticolimbic areas – medial prefrontal cortex, orbitofrontal cortex, striatum, nucleus accumbens and amygdala – 1 month after a neuropathic lesion, Spared Nerve Injury (SNI). In SNI animals, were observed a marginal decrease of DA and 5-HT in the striatum and a rightward shift in the levels of NA in the nucleus accumbens. While mesocorticolimbic monoamines might be relevant for chronic pain pathophysiology its content appears to be relatively unaffected in our experimental conditions. © 2020 Elsevier B.V.
Συγγραφείς:
Cunha, A.M.
Guimarães, M.R.
Kokras, N.
Sotiropoulos, I.
Sousa, N.
Almeida, A.
Dalla, C.
Leite-Almeida, H.
Περιοδικό:
Neuroscience Letters
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
3,4 dihydroxyphenylacetic acid; 5 hydroxyindoleacetic acid; dopamine; homovanillic acid; monoamine; noradrenalin; serotonin; dopamine; noradrenalin; serotonin, amygdala; animal experiment; animal model; animal tissue; Article; basal ganglion; chronic pain; controlled study; corpus striatum; dopaminergic activity; hemispheric dominance; high performance liquid chromatography; left hemisphere; male; mechanical allodynia; medial prefrontal cortex; monoamine metabolism; monoaminergic system; neuropathic pain; nonhuman; nucleus accumbens; orbital cortex; pathophysiology; priority journal; rat; right hemisphere; spared nerve injury; turnover rate; amygdala; animal; corpus striatum; frontal lobe; metabolism; neuralgia; nucleus accumbens; Wistar rat, Amygdala; Animals; Corpus Striatum; Dopamine; Frontal Lobe; Male; Neuralgia; Norepinephrine; Nucleus Accumbens; Rats; Rats, Wistar; Serotonin
DOI:
10.1016/j.neulet.2020.135309
