Τίτλος:
Neuropsychological and syntactic deficits in HIV seropositive males
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Given the underlying frontal-basal ganglia circuit neuropathogenesis of HIV-infected individuals, it is surprising that little is reported about potential language deficits as part of their higher cognitive dysfunctional profile. This study aims to elucidate whether HIV-positive individuals have linguistic impairments that may originate from or be intensified by deficits in cognitive functions. The research questions address (i) quantitative differences in sentence repetition abilities involving complex syntactic phenomena between adults with HIV and non-HIV healthy controls (ii) correlations of sentence repetition scores with neurocognitive measures and (iii) correlation of sentence repetition performance with duration and severity of HIV. Methods: A battery of neuropsychological tests were administered to 40 HIV-seropositive males and 40 demographically matched healthy controls to assess verbal learning/episodic memory, psychomotor speed, executive functions and visuospatial abilities. Language abilities were evaluated using a repetition task that screened specific complex syntactic operations at the sentence-level. Results: A significant difference was noted between the two groups regarding correct repetition of the sentence repetition task with the control group outperforming the HIV-seropositive group. For the HIV group, significant correlations were found for correct sentence repetition with years of education, duration of illness, Mini-Mental State Examination, semantic and phonemic fluency, symbol digit modality test scores, and the Trail Making Test (parts A and B). Conclusion: Speech-language pathologists and neuropsychologists should screen for language deficits associated with the different clinical syndromes in HIV patients as part of their routine clinical care. © 2019 Kambanaros et al.
Συγγραφείς:
Kambanaros, M.
Messinis, L.
Psichogiou, M.
Leonidou, L.
Gogos, C.A.
Nasios, G.
Papathanasopoulos, P.
Περιοδικό:
The Open Neurology Journal
Εκδότης:
Bentham Science Publishers
Λέξεις-κλειδιά:
adult; Article; cognitive defect; controlled study; disease duration; disease severity; disorders of higher cerebral function; educational status; episodic memory; executive function; female; Hospital Anxiety and Depression Scale; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; jSentence and syntactic structure repetition test; language disability; Line Orientation Test; major clinical study; male; Mini Mental State Examination; neuropsychological test; priority journal; psychomotor performance; Repeatable Battery for the Assessment of Neuropsychological Status; Rey auditory verbal learning test; Stroop test; symbol digit modalities test; task performance; trail making test; verbal learning; Visuospatial Index
DOI:
10.2174/1874205X01913010107
