Περίληψη:
The onset and growth of subependymal giant cell astrocytoma (SEGA) in tuberous sclerosis complex (TSC) typically occurs in childhood. There is minimal information on SEGA evolution in adults with TSC. Of 2,211 patients enrolled in TOSCA, 220 of the 803 adults (27.4%) ever had a SEGA. Of 186 patients with SEGA still ongoing in adulthood, 153 (82.3%) remained asymptomatic, and 33 (17.7%) were reported to ever have developed symptoms related to SEGA growth. SEGA growth since the previous scan was reported in 39 of the 186 adults (21%) with ongoing SEGA. All but one patient with growing SEGA had mutations in TSC2. Fourteen adults (2.4%) were newly diagnosed with SEGA during follow-up, and majority had mutations in TSC2. Our findings suggest that surveillance for new or growing SEGA is warranted also in adulthood, particularly in patients with mutations in TSC2. © 2019 Jansen, Belousova, Benedik, Carter, Cottin, Curatolo, D'Amato, Beaure d'Augères, de Vries, Ferreira, Feucht, Fladrowski, Hertzberg, Jozwiak, Lawson, Macaya, Marques, Nabbout, O'Callaghan, Qin, Sander, Sauter, Shah, Takahashi, Touraine, Youroukos, Zonnenberg and Kingswood.
Συγγραφείς:
Jansen, A.C.
Belousova, E.
Benedik, M.P.
Carter, T.
Cottin, V.
Curatolo, P.
D'Amato, L.
D'Augères, G.B.
De Vries, P.J.
Ferreira, J.C.
Feucht, M.
Fladrowski, C.
Hertzberg, C.
Jozwiak, S.
Lawson, J.A.
MacAya, A.
Marques, R.
Nabbout, R.
O'Callaghan, F.
Qin, J.
Sander, V.
Sauter, M.
Shah, S.
Takahashi, Y.
Touraine, R.
Youroukos, S.
Zonnenberg, B.
Kingswood, J.C.
Fladrowsk, C.
Shinohara, N.
Horie, S.
Kubota, M.
Tohyama, J.
Imai, K.
Kaneda, M.
Kaneko, H.
Uchida, Y.
Kirino, T.
Endo, S.
Inoue, Y.
Uruno, K.
Serdaroglu, A.
Yapici, Z.
Anlar, B.
Altunbasak, S.
Lvova, O.
Belyaev, O.V.
Agranovich, O.
Levitina, E.V.
Maksimova, Y.V.
Karas, A.
Jiang, Y.
Zou, L.
Xu, K.
Zhang, Y.
Luan, G.
Zhang, Y.
Wang, Y.
Jin, M.
Ye, D.
Liao, W.
Zhou, L.
Liu, J.
Liao, J.
Yan, B.
Deng, Y.
Jiang, L.
Liu, Z.
Huang, S.
Li, H.
Kim, K.
Chen, P.-L.
Lee, H.-F.
Tsai, J.-D.
Chi, C.-S.
Huang, C.-C.
Riney, K.
Yates, D.
Kwan, P.
Likasitwattanakul, S.
Nabangchang, C.
Krisnachai Chomtho, L.T.
Katanyuwong, K.
Sriudomkajorn, S.
Wilmshurst, J.
Segel, R.
Gilboa, T.
Tzadok, M.
Fattal-Valevski, A.
Papathanasopoulos, P.
Papavasiliou, A.S.
Giannakodimos, S.
Gatzonis, S.
Pavlou, E.
Tzoufi, M.
Vergeer, A.M.H.
Dhooghe, M.
Verhelst, H.
Roelens, F.
Nassogne, M.C.
Defresne, P.
De Waele, L.
Leroy, P.
Demonceau, N.
Legros, B.
Van Bogaert, P.
Ceulemans, B.
Dom, L.
Castelnau, P.
De Saint Martin, A.
Riquet, A.
Milh, M.
Cances, C.
Pedespan, J.-M.
Ville, D.
Roubertie, A.
Auvin, S.
Berquin, P.
Richelme, C.
Allaire, C.
Gueden, S.
The Tich, S.N.
Godet, B.
Ruiz Falco Rojas, M.L.
Planas, J.C.
Bermejo, A.M.
Dura, P.S.
Aparicio, S.R.
Martinez Gonzalez, M.J.
Pison, J.L.
Blanco Barca, M.O.
Laso, E.L.
Luengo, O.A.
Aguirre Rodriguez, F.J.
Dieguez, I.M.
Salas, A.C.
Carrera, I.M.
Salcedo, E.M.
Yoldi Petri, M.E.
Candela, R.C.
Da Conceicao Carrilho, I.
Vieira, J.P.
Da Silva Oliveira Monteiro, J.P.
Santos De Oliveira Ferreira Leao, M.J.
Marceano Ribeiro Luis, C.S.
Mendonca, C.P.
Endziniene, M.
Strautmanis, J.
Talvik, I.
Canevini, M.P.
Gambardella, A.
Pruna, D.
Buono, S.
Fontana, E.
Dalla Bernardina, B.
Burloiu, C.
Bacos Cosma, I.S.
Vintan, M.A.
Popescu, L.
Zitterbart, K.
Payerova, J.
Bratsky, L.
Zilinska, Z.
Gruber-Sedlmayr, U.
Baumann, M.
Haberlandt, E.
Rostasy, K.
Pataraia, E.
Elmslie, F.
Johnston, C.A.
Crawford, P.
Uldall, P.
Dahlin, M.
Uvebrant, P.
Rask, O.
Bjoernvold, M.
Brodtkorb, E.
Sloerdahl, A.
Solhoff, R.
Gilje Jaatun, M.S.
Mandera, M.
Radzikowska, E.J.
Wysocki, M.
Fischereder, M.
Kurlemann, G.
Wilken, B.
Wiemer-Kruel, A.
Budde, K.
Marquard, K.
Knuf, M.
Hahn, A.
Hartmann, H.
Merkenschlager, A.
Trollmann, R.
on behalf of TOSCA Consortium
TOSCA Investigators
