Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:2999799 115 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. © 2021 The Authors, some rights reserved.
Έτος δημοσίευσης:
2021
Συγγραφείς:
Bastard, P.
Gervais, A.
Voyer, T.L.
Rosain, J.
Philippot, Q.
Manry, J.
Michailidis, E.
Hoffmann, H.-H.
Eto, S.
Garcia-Prat, M.
Bizien, L.
Parra-Martínez, A.
Yang, R.
Haljasmägi, L.
Migaud, M.
Särekannu, K.
Maslovskaja, J.
De Prost, N.
Tandjaoui-Lambiotte, Y.
Luyt, C.-E.
Amador-Borrero, B.
Gaudet, A.
Poissy, J.
Morel, P.
Richard, P.
Cognasse, F.
Troya, J.
Trouillet-Assant, S.
Belot, A.
Saker, K.
Garçon, P.
Rivière, J.G.
Lagier, J.-C.
Gentile, S.
Rosen, L.B.
Shaw, E.
Morio, T.
Tanaka, J.
Dalmau, D.
Tharaux, P.-L.
Sene, D.
Stepanian, A.
Megarbane, B.
Triantafyllia, V.
Fekkar, A.
Heath, J.R.
Franco, J.L.
Anaya, J.-M.
Solé-Violán, J.
Imberti, L.
Biondi, A.
Bonfanti, P.
Castagnoli, R.
Delmonte, O.M.
Zhang, Y.
Snow, A.L.
Holland, S.M.
Biggs, C.M.
Moncada-Vélez, M.
Arias, A.A.
Lorenzo, L.
Boucherit, S.
Coulibaly, B.
Anglicheau, D.
Planas, A.M.
Haerynck, F.
Duvlis, S.
Nussbaum, R.L.
Ozcelik, T.
Keles, S.
Bousfiha, A.A.
El Bakkouri, J.
Ramirez-Santana, C.
Paul, S.
Pan-Hammarström, Q.
Hammarström, L.
Dupont, A.
Kurolap, A.
Metz, C.N.
Aiuti, A.
Casari, G.
Lampasona, V.
Ciceri, F.
Barreiros, L.A.
Dominguez-Garrido, E.
Vidigal, M.
Zatz, M.
Van De Beek, D.
Sahanic, S.
Tancevski, I.
Stepanovskyy, Y.
Boyarchuk, O.
Nukui, Y.
Tsumura, M.
Vidaur, L.
Tangye, S.G.
Burrel, S.
Duffy, D.
Quintana-Murci, L.
Klocperk, A.
Kann, N.Y.
Shcherbina, A.
Lau, Y.-L.
Leung, D.
Coulongeat, M.
Marlet, J.
Koning, R.
Reyes, L.F.
Chauvineau-Grenier, A.
Venet, F.
Monneret, G.
Nussenzweig, M.C.
Arrestier, R.
Boudhabhay, I.
Baris-Feldman, H.
Hagin, D.
Wauters, J.
Meyts, I.
Dyer, A.H.
Kennelly, S.P.
Bourke, N.M.
Halwani, R.
Sharif-Askari, N.S.
Dorgham, K.
Sallette, J.
Sedkaoui, S.M.
AlKhater, S.
Rigo-Bonnin, R.
Morandeira, F.
Roussel, L.
Vinh, D.C.
Ostrowski, S.R.
Condino-Neto, A.
Prando, C.
Bondarenko, A.
Spaan, A.N.
Gilardin, L.
Fellay, J.
Lyonnet, S.
Bilguvar, K.
Lifton, R.P.
Mane, S.
Anderson, M.S.
Boisson, B.
Béziat, V.
Zhang, S.-Y.
Andreakos, E.
Hermine, O.
Pujol, A.
Peterson, P.
Mogensen, T.H.
Rowen, L.
Mond, J.
Debette, S.
De Lamballerie, X.
Duval, X.
Mentré, F.
Zins, M.
Soler-Palacin, P.
Colobran, R.
Gorochov, G.
Solanich, X.
Susen, S.
Martinez-Picado, J.
Raoult, D.
Vasse, M.
Gregersen, P.K.
Piemonti, L.
Rodríguez-Gallego, C.
Notarangelo, L.D.
Su, H.C.
Kisand, K.
Okada, S.
Puel, A.
Jouanguy, E.
Rice, C.M.
Tiberghien, P.
Zhang, Q.
Cobat, A.
Abel, L.
Casanova, J.-L.
Alavoine, L.
Behillil, S.
Burdet, C.
Charpentier, C.
Dechanet, A.
Descamps, D.
Ecobichon, J.-L.
Enouf, V.
Frezouls, W.
Houhou, N.
Kafif, O.
Lehacaut, J.
Letrou, S.
Lina, B.
Lucet, J.-C.
Manchon, P.
Nouroudine, M.
Piquard, V.
Quintin, C.
Thy, M.
Tubiana, S.
Van Der Werf, S.
Vignali, V.
Visseaux, B.
Yazdanpanah, Y.
Chahine, A.
Waucquier, N.
Migaud, M.-C.
Deplanque, D.
Djossou, F.
Mergeay-Fabre, M.
Lucarelli, A.
Demar, M.
Bruneau, L.
Gerardin, P.
Maillot, A.
Payet, C.
Laviolle, B.
Laine, F.
Paris, C.
Desille-Dugast, M.
Fouchard, J.
Malvy, D.
Nguyen, D.
Pistone, T.
Perreau, P.
Gissot, V.
Le Goas, C.
Montagne, S.
Richard, L.
Chirouze, C.
Bouiller, K.
Desmarets, M.
Meunier, A.
Lefevre, B.
Jeulin, H.
Legrand, K.
Lomazzi, S.
Tardy, B.
Gagneux-Brunon, A.
Bertholon, F.
Botelho-Nevers, E.
Christelle, K.
Nicolas, L.
Roufai, L.
Amat, K.
Couffin-Cadiergues, S.
Esperou, H.
Hendou, S.
Townsend, L.
Cheallaigh, C.N.
Bergin, C.
Martin-Loeches, I.
Dunne, J.
Conlon, N.
O'Farrelly, C.
Abad, J.
Accordino, G.
Achille, C.
Aguilera-Albesa, S.
Aguilo-Cucurull, A.
Ozkan, E.A.
Darazam, I.A.
Albisures, J.A.R.
Aldave, J.C.
Ramos, M.A.
Khan, T.A.
Aliberti, A.
Nadji, S.A.
Alkan, G.
AlKhater, S.A.
Allardet-Servent, J.
Allende, L.M.
Alonso-Arias, R.
Alshahrani, M.S.
Alsina, L.
Alyanakian, M.-A.
Borrero, B.A.
Amoura, Z.
Antoli, A.
Aubart, M.
Auguet, T.
Avramenko, I.
Aytekin, G.
Azot, A.
Bahram, S.
Bajolle, F.
Baldanti, F.
Baldolli, A.
Ballester, M.
Feldman, H.B.
Barrou, B.
Barzaghi, F.
Basso, S.
Bayhan, G.I.
Bezrodnik, L.
Bilbao, A.
Blanchard-Rohner, G.
Blanco, I.
Blandinieres, A.
Blazquez-Gamero, D.
Bleibtreu, A.
Bloomfield, M.
Bolivar-Prados, M.
Borghesi, A.
Borie, R.
Botdhlo-Nevers, E.
Bousquet, A.
Boutolleau, D.
Bouvattier, C.
Bravais, J.
Briones, M.L.
Brunner, M.-E.
Bruno, R.
Bueno, M.R.P.
Bukhari, H.
Bustamante, J.
Agra, J.J.C.
Capra, R.
Carapito, R.
Carrabba, M.
Casasnovas, C.
Caseris, M.
Cassaniti, I.
Castelle, M.
Castelli, F.
De Vera, M.C.
Castro, M.V.
Catherinot, E.
Celik, J.B.
Ceschi, A.
Chalumeau, M.
Charbit, B.
Cheng, M.P.
Clave, P.
Clotet, B.
Codina, A.
Cohen, Y.
Comarmond, C.
Combes, A.
Comoli, P.
Corsico, A.G.
Coşkuner, T.
Cvetkovski, A.
Cyrus, C.
Danion, F.
Darley, D.R.
Das, V.
Dauby, N.
Dauger, S.
De Munter, P.
De Pontual, L.
Dehban, A.
Delplancq, G.
Demoule, A.
Desguerre, I.
Di Sabatino, A.
Diehl, J.-L.
Dobbelaere, S.
Dubost, C.
Ekwall, O.
Bozdemir, Ş.E.
Elnagdy, M.H.
Emiroglu, M.
Endo, A.
Erdeniz, E.H.
Aytekin, S.E.
Lasa, M.P.E.
Euvrard, R.
Fabio, G.
Faivre, L.
Falck, A.
Fartoukh, M.
Faure, M.
Arquero, M.F.
Ferrer, R.
Ferreres, J.
Flores, C.
Francois, B.
Fumado, V.
Fung, K.S.C.
Fusco, F.
Gagro, A.
Solis, B.G.
Gaussem, P.
Gayretli, Z.
Gil-Herrera, J.
Gatineau, A.G.
Girona-Alarcon, M.
Godinez, K.A.C.
Goffard, J.-C.
Gonzales, N.
Gonzalez-Granado, L.I.
Gonzalez-Montelongo, R.
Guerder, A.
Gulhan, B.
Gumucio, V.D.
Hanitsch, L.G.
Gunst, J.
Gut, M.
Hadjadj, J.
Hancerli, S.
Hariyan, T.
Hatipoglu, N.
Heppekcan, D.
Hernandez-Brito, E.
Ho, P.-K.
Holanda-Pena, M.S.
Horcajada, J.P.
Hraiech, S.
Humbert, L.
Hung, I.F.N.
Iglesias, A.D.
Inigo-Campos, A.
Jamme, M.
Arranz, M.J.
Jimeno, M.-T.
Jordan, I.
Kanik-Yuksek, S.
Kara, Y.B.
Karahan, A.
Karbuz, A.
Yasar, K.K.
Kasapcopur, O.
Kashimada, K.
Demirkol, Y.K.
Kido, Y.
Kizil, C.
Kilic, A.O.
Koutsoukou, A.
Krol, Z.J.
Ksouri, H.
Kuentz, P.
Kwan, A.M.C.
Kwan, Y.W.M.
Kwok, J.S.Y.
Lam, D.S.Y.
Lampropoulou, V.
Lanternier, F.
Le Bourgeois, F.
Leo, Y.-S.
Lopez, R.L.
Levin, M.
Levy, M.
Levy, R.
Li, Z.
Lilleri, D.
Lima, E.J.A.B.
Linglart, A.
Lopez-Collazo, E.
Lorenzo-Salazar, J.M.
Louapre, C.
Lubetzki, C.
Lung, K.-C.
Lye, D.C.
Magnone, C.
Mansouri, D.
Marchioni, E.
Marioli, C.
Marjani, M.
Marques, L.
Pereira, J.M.
Martin-Nalda, A.
Pueyo, D.M.
Marzana, I.
Mata-Martinez, C.
Mathian, A.
Matos, L.R.B.
Matthews, G.V.
Mayaux, J.
McLaughlin-Garcia, R.
Meersseman, P.
Mege, J.-L.
Mekontso-Dessap, A.
Melki, I.
Meloni, F.
Meritet, J.-F.
Merlani, P.
Akcan, O.M.
Mezidi, M.
Migeotte, I.
Millereux, M.
Million, M.
Mirault, T.
Mircher, C.
Mirsaeidi, M.
Mizoguchi, Y.
Modi, B.P.
Mojoli, F.
Moncomble, E.
Melian, A.M.
Martinez, A.M.
Morange, P.-E.
Mordacq, C.
Morelle, G.
Mouly, S.J.
Munoz-Barrera, A.
Nafati, C.
Nagashima, S.
Nakagama, Y.
Neven, B.
Neves, J.F.
Ng, L.F.P.
Ng, Y.-Y.
Nielly, H.
Medina, Y.N.
Cuadros, E.N.
Ocejo-Vinyals, J.G.
Okamoto, K.
Oualha, M.
Ouedrani, A.
Ozkaya-Parlakay, A.
Pagani, M.
Papadaki, M.
Parizot, C.
Parola, P.
Pascreau, T.
Paz-Artal, E.
Pedraza, S.
Pellecer, N.C.G.
Pellegrini, S.
De Diego, R.P.
Perez-Fernandez, X.L.
Philippe, A.
Picod, A.
De Chambrun, M.P.
Piralla, A.
Planas-Serra, L.
Ploin, D.
Poncelet, G.
Poulakou, G.
Pouletty, M.S.
Pourshahnazari, P.
Qiu-Chen, J.L.
Quentric, P.
Rambaud, T.
Raoult, V.
Rebillat, A.-S.
Redin, C.
Resmini, L.
Ricart, P.
Richard, J.-C.
Rivet, N.
Rocamora-Blanch, G.
Rodero, M.P.
Rodrigo, C.
Rodriguez, L.A.
Rodriguez-Palmero, A.
Romero, C.S.
Rothenbuhler, A.
Roux, D.
Rovina, N.
Rozenberg, F.
Ruch, Y.
Ruiz, M.
Del Prado, M.Y.R.
Ruiz-Rodriguez, J.C.
Sabater-Riera, J.
Saks, K.
Salagianni, M.
Sanchez, O.
Sanchez-Montalva, A.
Sanchez-Ramon, S.
Schidlowski, L.
Schluter, A.
Schmidt, J.
Schmidt, M.
Schuetz, C.
Schweitzer, C.E.
Scolari, F.
Sediva, A.
Seijo, L.
Seminario, A.G.
Seng, P.
Senoglu, S.
Seppanen, M.
Llovich, A.S.
Shahrooei, M.
Siguret, V.
Siouti, E.
Smadja, D.M.
Smith, N.
Sobh, A.
Soler, C.
Sozeri, B.
Stella, G.M.
Stepanovskiy, Y.
Stoclin, A.
Taccone, F.
Taupin, J.-L.
Tavernier, S.J.
Terrier, B.
Thiery, G.
Thorball, C.
Thorn, K.
Thumerelle, C.
Tipu, I.
Tolstrup, M.
Tomasoni, G.
Toubiana, J.
Alvarez, J.T.
Tsang, O.T.Y.
Tserel, L.
Tso, E.Y.K.
Tucci, A.
Oz, Ş.K.T.
Ursini, M.V.
Utsumi, T.
Uzunhan, Y.
Vabres, P.
Valencia-Ramos, J.
Van Den Rym, A.M.
Vandernoot, I.
Velez-Santamaria, V.
Veliz, S.P.Z.
Vidigal, M.C.
Viel, S.
Vilain, C.
Vilaire-Meunier, M.E.
Villar-Garcia, J.
Vincent, A.
Vogt, G.
Voiriot, G.
Volokha, A.
Vuotto, F.
Wauters, E.
Wu, A.K.L.
Wu, T.-C.
Yahşi, A.
Yesilbas, O.
Yildiz, M.
Young, B.E.
Yukselmiş, U.
Zecca, M.
Zuccaro, V.
Van Praet, J.
Lambrecht, B.N.
Van Braeckel, E.
Bosteels, C.
Hoste, L.
Hoste, E.
Bauters, F.
De Clercq, J.
Heijmans, C.
Slabbynck, H.
Naesens, L.
Florkin, B.
Boulanger, C.
Vanderlinden, D.
Allavena, C.
Andrejak, C.
Angoulvant, F.
Azoulay, C.
Bachelet, D.
Bartoli, M.
Basmaci, R.
Behillill, S.
Beluze, M.
Benech, N.
Benkerrou, D.
Bhavsar, K.
Bitker, L.
Bouadma, L.
Bouscambert-Duchamp, M.
Paz, P.C.
Cervantes-Gonzalez, M.
Chair, A.
Coelho, A.
Cordel, H.
Couffignal, C.
D'Ortenzio, E.
De Montmollin, E.
Debard, A.
Debray, M.-P.
Desvallee, M.
Diallo, A.
Diouf, A.
Dorival, C.
Dubos, F.
Eloy, P.
Epaulard, O.
Esposito-Farase, M.
Etienne, M.
Garot, D.
Gault, N.
Gaymard, A.
Ghosn, J.
Gigante, T.
Gilg, M.
Goehringer, F.
Guedj, J.
Hoctin, A.
Hoffmann, I.
Houas, I.
Hulot, J.-S.
Jaafoura, S.
Kaguelidou, F.
Kali, S.
Kerroumi, Y.
Khalil, A.
Khan, C.
Kimmoun, A.
Laouenan, C.
Laribi, S.
Le, M.
Le Bris, C.
Le Gac, S.
Le Hingrat, Q.
Le Mestre, S.
Le Nagard, H.
Lemaignen, A.
Lemee, V.
Lescure, F.-X.
Levy, Y.
Lingas, G.
Lucet, J.C.
MacHado, M.
Mambert, M.
Manuel, A.
Meziane, A.
Mouquet, H.
Mullaert, J.
Neant, N.
Noret, M.
Papadopoulos, A.
Paul, C.
Peiffer-Smadja, N.
Peigne, V.
Petrov-Sanchez, V.
Peytavin, G.
Pham, H.
Picone, O.
Puechal, O.
Rosa-Calatrava, M.
Rossignol, B.
Rossignol, P.
Roy, C.
Schneider, M.
Su, R.
Tardivon, C.
Tellier, M.-C.
Teoule, F.
Terrier, O.
Timsit, J.F.
Tual, C.
Vanel, N.
Veislinger, A.
Wiedemann, A.
Danielson, J.J.
Dobbs, K.
Kashyap, A.
Ding, L.
Dalgard, C.L.
Sottini, A.
Quaresima, V.
Quiros-Roldan, E.
Rossi, C.
Bettini, L.R.
D'Angio, M.
Beretta, I.
Montagna, D.
Licari, A.
Marseglia, G.L.
Storgaard, M.
Jorgensen, S.
Al-Muhsen, S.
Al-Mulla, F.
Arias, A.A.
Bogunovic, D.
Bolze, A.
Brodin, P.
Bryceson, Y.
Bustamante, C.D.
Butte, M.J.
Chakravorty, S.
Christodoulou, J.
Constantinescu, S.N.
Cooper, M.A.
Desai, M.
Drolet, B.A.
El Baghdadi, J.
Espinosa-Padilla, S.
Froidure, A.
Henrickson, S.E.
Hsieh, E.W.Y.
Husebye, E.S.
Imai, K.
Itan, Y.
Jarvis, E.D.
Karamitros, T.
Ku, C.-L.
Ling, Y.
Lucas, C.L.
Maniatis, T.
Marodi, L.
Milner, J.D.
Mironska, K.
Novelli, A.
Novelli, G.
Renia, L.
Resnick, I.
Sancho-Shimizu, V.
Seppanen, M.R.J.
Shahrooei, M.
Slaby, O.
Tayoun, A.A.
Ramaswamy, S.
Turvey, S.E.
Furkan Uddin, K.M.
Uddin, M.J.
Von Bernuth, H.
Zawadzki, P.
Bigio, B.
De La Chapelle, A.
Chen, J.
Chrabieh, M.
Liu, D.
Nemirowskaya, Y.
Cruz, I.M.
Materna, M.
Pelet, S.
Seeleuthner, Y.
Thibault, C.
Liu, Z.
Foti, G.
Bellani, G.
Citerio, G.
Contro, E.
Pesci, A.
Valsecchi, M.G.
Cazzaniga, M.
Batten, I.
Reddy, C.
McElheron, M.
Noonan, C.
Connolly, E.
Fallon, A.
Erikstrup, C.
Pedersen, O.B.
Sorensen, E.
Mikkelsen, S.
Dinh, K.M.
Larsen, M.A.H.
Paulsen, I.W.
Von Stemann, J.H.
Hansen, M.B.
Annereau, J.-P.
Briseno-Roa, L.
Gribouval, O.
Pelet, A.
Alcover, A.
Aschard, H.
Bousso, P.
Bruhns, P.
Cerf-Bensussan, N.
Cumano, A.
D'Enfert, C.
Deriano, L.
Dillies, M.-A.
Di Santo, J.
Dromer, F.
Eberl, G.
Enninga, J.
Gomperts-Boneca, I.
Hasan, M.
Hedestam, G.K.
Hercberg, S.
Ingersoll, M.A.
Lantz, O.
Kenny, R.A.
Menager, M.
Michel, F.
Patin, E.
Pellegrini, S.
Rausell, A.
Rieux-Laucat, F.
Rogge, L.
Fontes, M.
Sakuntabhai, A.
Schwartz, O.
Schwikowski, B.
Shorte, S.
Tangy, F.
Toubert, A.
Touvier, M.
Ungeheuer, M.-N.
Zimmer, C.
Albert, M.L.
Van Agtmael, M.
Algera, A.G.
Appelman, B.
Van Baarle, F.
Bax, D.
Beudel, M.
Bogaard, H.J.
Bomers, M.
Bonta, P.
Bos, L.
Botta, M.
De Brabander, J.
De Bree, G.
De Bruin, S.
Buis, D.T.P.
Bugiani, M.
Bulle, E.
Chouchane, O.
Cloherty, A.
Dijkstra, M.
Dongelmans, D.A.
Dujardin, R.W.G.
Elbers, P.
Fleuren, L.
Geerlings, S.
Geijtenbeek, T.
Girbes, A.
Goorhuis, B.
Grobusch, M.P.
Hafkamp, F.
Hagens, L.
Hamann, J.
Harris, V.
Hemke, R.
Hermans, S.M.
Heunks, L.
Hollmann, M.
Horn, J.
Hovius, J.W.
De Jong, M.D.
Lim, E.H.T.
Van Mourik, N.
Nellen, J.
Nossent, E.J.
Paulus, F.
Peters, E.
Pina-Fuentes, D.A.I.
Van Der Poll, T.
Preckel, B.
Prins, J.M.
Raasveld, J.
Reijnders, T.
De Rotte, M.C.F.J.
Schinkel, M.
Schultz, M.J.
Schrauwen, F.A.P.
Schuurman, A.
Schuurmans, J.
Sigaloff, K.
Slim, M.A.
Smeele, P.
Smit, M.
Stijnis, C.S.
Stilma, W.
Teunissen, C.
Thoral, P.
Tsonas, A.M.
Tuinman, P.R.
Van Der Valk, M.
Veelo, D.
Volleman, C.
De Vries, H.
Vught, L.A.
Van Vugt, M.
Wouters, D.
Zwinderman, A.H.
Brouwer, M.C.
Joost Wiersinga, W.
Vlaar, A.P.J.
Nadif, R.
Goldberg, M.
Ozguler, A.
Henny, J.
Lemonnier, S.
Coeuret-Pellicer, M.
Le Got, S.
Tzourio, C.
Dufouil, C.
Soumare, A.
Lachaize, M.
Fievet, N.
Flaig, A.
Martin, F.
Bonneaudeau, B.
Cannet, D.
Gallian, P.
Jeanne, M.
Perroquin, M.
Hamzeh-Cognasse, H.
CoV-Contact Cohort
St James's Hospital, SARS CoV2 Interest group
COVID Clinicians
French COVID Cohort Study Group
NIAID Immune Response to COVID Group
Danish CHGE
COVID Human Genetic Effort
HGID Lab
COVID-STORM Clinicians
NH-COVAIR Study Group
The Danish Blood Donor Study (DBDS)
Imagine COVID-Group
The Milieu Interieur Consortium
Amsterdam UMC Covid-19 Biobank
CONSTANCES cohort
3C-Dijon Study
Cerba HealthCare
Etablissement du Sang study group
Περιοδικό:
Science Immunology
Εκδότης:
American Association for the Advancement of Science
Τόμος:
6
Αριθμός / τεύχος:
62
Λέξεις-κλειδιά:
alpha2 interferon; autoantibody; interferon; omega interferon; alpha interferon; autoantibody; immunoglobulin G; interferon; interferon omega 1; neutralizing antibody, adolescent; adult; aged; antibody detection; Article; child; cohort analysis; controlled study; coronavirus disease 2019; critically ill patient; disease severity; enzyme linked immunosorbent assay; fatality; female; human; infant; major clinical study; male; mortality rate; prevalence; protein blood level; virus neutralization; virus replication; blood; case control study; critical illness; immunology; middle aged; mortality; newborn; preschool child; very elderly; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Neutralizing; Autoantibodies; Case-Control Studies; Child; Child, Preschool; COVID-19; Critical Illness; Humans; Immunoglobulin G; Infant; Infant, Newborn; Interferon Type I; Interferon-alpha; Middle Aged; Young Adult
Επίσημο URL (Εκδότης):
DOI:
10.1126/sciimmunol.abl4340
Το ψηφιακό υλικό του τεκμηρίου δεν είναι διαθέσιμο.