Τίτλος:
Histamine H3 and H4 Receptor Ligands Modify Vascular Histamine Levels in Normal and Arthritic Large Blood Vessels In Vivo
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Growing evidence associates histamine with arthritis, but its implication in shaping vascular function in chronic inflammation remains largely elusive. This study explored the involvement of vascular histamine in the extra-articular responses in peripheral large blood vessels using a rat model of adjuvant-induced arthritis. Histamine levels were increased in the abdominal aorta and the inferior vena cava of arthritic animals. Contrary to the H1 receptor antagonist dimetindene, histamine induction was observed following administration of the H3 and H4 receptor ligands GSK334429 and JNJ7777120, respectively. In arthritis, prophylactic treatment with GSK334429 partially attenuated the clinical signs and restored basal histamine levels only in the abdominal aorta. This study is the first to implicate the H3 and H4 receptors in a concerted constitutive regulation of basal vascular histamine in the rat large blood vessels and to identify the H3 receptor as a component that may influence arterial histamine during the onset of arthritis. © 2014, Springer Science+Business Media New York.
Συγγραφείς:
Kyriakidis, K.
Zampeli, E.
Palaiologou, M.
Tiniakos, D.
Tiligada, E.
Περιοδικό:
Journal of Inflammation Research
Εκδότης:
Springer New York LLC
Λέξεις-κλειδιά:
1 (5 chloro 2 indolylcarbonyl) 4 methylpiperazine; dimetindene; GSK334429; histamine; histamine H3 receptor; histamine H3 receptor antagonist; histamine H4 receptor; unclassified drug; 1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine; 1-(1-methylethyl)-4-((1-(6-(trifluoromethyl)-3-pyridinyl)-4-piperidinyl)carbonyl)hexahydro-1H-1,4-diazepine; antiinflammatory agent; azepine derivative; dimetindene; Freund adjuvant; G protein coupled receptor; histamine H1 receptor antagonist; histamine H3 receptor; histamine H3 receptor antagonist; histamine receptor; Hrh4 protein, rat; indole derivative; piperazine derivative; pyridine derivative, abdominal aorta; adjuvant arthritis; animal experiment; animal model; animal tissue; Article; controlled study; endothelium; experimental arthritis; great blood vessel; histamine blood level; in vivo study; inferior cava vein; male; nonhuman; phenotype; rat; animal; aorta; blood; inflammation; metabolism; pathology; Wistar rat, Animalia; Rattus, Animals; Anti-Inflammatory Agents; Aorta; Arthritis, Experimental; Azepines; Dimethindene; Endothelium; Freund's Adjuvant; Histamine; Histamine H1 Antagonists; Histamine H3 Antagonists; Indoles; Inflammation; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H3; Vena Cava, Inferior
DOI:
10.1007/s10753-014-0057-1
