Τίτλος:
Limited Long-Term Naive CD4+ T Cell Reconstitution in Patients Experiencing Viral Load Rebounds during HAART
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Long-term (3.5 years) immune reconstitution in relation to viral load response was determined. Plasma HIV-1 RNA was suppressed in 40 patients (full responders) up to 42 months, and 17 patients achieved partial response. The measurements of CD4+ and CD8+ T lymphocyte subsets (CD45RA, CD45RACD62L, CD45RO, CD28, CD38) were carried out by flow cytometry. Full responders had a significant increase of CD4+ and all CD4 + T subsets both up to 6 and from 6 to 42 months, while the increase for partial responders was only up to 6 months. By 6 months, higher slopes were observed in full versus partial responders in the % of CD28 on CD4+ and the % of CD4+ memory subset and in both naïve and memory CD4+ subsets from 6 to 42 months. The percentage of CD8+ and its subsets was decreased significantly in full responders both up to 6 and from 6 to 42 months (except for an increase in the CD8+CD45RA + CD62L+ cells), while in partial responders this decrease was only up to 6 months. Lower slopes were observed in full versus partial responders from 6 to 42 months in the percentages of CD8+, CD8+CD45RO+, CD8+CD28-, and CD8 +CD38+ T cells. In conclusion, full responders have a stronger long-term naive CD4+ T cell subset reconstitution than partial responders. © 2004 Wiley-Liss, Inc.
Συγγραφείς:
Choremi-Papadopoulou, H.
Tsalimalma, K.
Dafni, U.
Dimitracopoulou, A.
Kordossis, T.
Περιοδικό:
Journal of Medical Virology
Λέξεις-κλειδιά:
antiretrovirus agent; CD28 antigen; CD38 antigen; CD4 antigen; CD45 antigen; CD8 antigen; indinavir; lamivudine; proteinase inhibitor; ritonavir; RNA directed DNA polymerase inhibitor; virus RNA; zidovudine, adult; antigen presenting cell; antigen recognition; article; clinical article; female; flow cytometry; highly active antiretroviral therapy; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; immune response; long term exposure; lymphocyte count; male; memory cell; statistical significance, Acquired Immunodeficiency Syndrome; ADP-ribosyl Cyclase; Adult; Antigens, CD; Antigens, CD28; Antigens, CD38; Antigens, CD4; Antigens, CD45; Antigens, CD8; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Female; Flow Cytometry; HIV Infections; HIV-1; Humans; Immunologic Memory; Immunophenotyping; Male; Membrane Glycoproteins; Middle Aged; RNA, Viral; T-Lymphocyte Subsets; Viral Load; Viremia, Human immunodeficiency virus 1
