Τίτλος:
HLA CLASS II POLYMORPHISM AND IDDM SUSCEPTIBILITY IN THE GREEK POPULATION
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The frequencies of HLA‐DQA1, DQB1 and DRB1 alleles were compared between 50 Insulin‐Dependent Diabetes Melitus (IDDM) patients and 49 healthy controls in the Greek population. Statistically significant difference in the frequencies of HLA‐DQA1*0501‐DQB1*0201 (P = 10‐4), DQA1*0301‐DQB1*0201 (P= 0.01) and DQA P0301‐DQB 1*0302 (P= 0.001) were observed. The DRB1*0405‐DQA1*0301‐DQB 1*0201 was the only DR, DQ combination significantly associated with the disease. The unexpected increase of DRB1*0405 observed in the Greek IDDM may suggest as reported in Chinese and Japanese IDDM a contribution of DRβ and DQα in susceptibility. Moreover, in contrast to the Asians, in the Greek, the DRβ, DQα are found with the usual DQβ 57‐ve. Copyright © 1993, Wiley Blackwell. All rights reserved
Συγγραφείς:
Khalil, I.
Spyropoulou, M.
Mallet, C.
Loste, M.N.
Douay, C.
Laperriere, J.
Bartzokas, C.
Lepage, V.
Charron, D.
Stavropoulos, C.
Περιοδικό:
International Journal of Immunogenetics
Λέξεις-κλειδιά:
HLA antigen class 2; HLA DQ antigen; HLA DR antigen, article; asia; china; controlled study; disease predisposition; gene frequency; genetic polymorphism; greece; human; insulin dependent diabetes mellitus; japan; priority journal, Adolescent; Adult; Algeria; Alleles; Autoimmune Diseases; Child; Child, Preschool; Comparative Study; Diabetes Mellitus, Insulin-Dependent; Disease Susceptibility; Ethnic Groups; Gene Frequency; Genetic Predisposition to Disease; Greece; Haplotypes; Histocompatibility Antigens Class II; Histocompatibility Testing; HLA-DQ Antigens; HLA-DR Antigens; Human; Japan; Polymerase Chain Reaction; Polymorphism (Genetics); Racial Stocks; Support, Non-U.S. Gov't
DOI:
10.1111/j.1744-313X.1993.tb00110.x
