Ερευνητικό υλικό ΕΚΠΑ

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Αγγλικά

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors. © 2020 Society for the Study of Addiction

2021

Munn-Chernoff, M.A.
Johnson, E.C.
Chou, Y.-L.
Coleman, J.R.I.
Thornton, L.M.
Walters, R.K.
Yilmaz, Z.
Baker, J.H.
Hübel, C.
Gordon, S.
Medland, S.E.
Watson, H.J.
Gaspar, H.A.
Bryois, J.
Hinney, A.
Leppä, V.M.
Mattheisen, M.
Ripke, S.
Yao, S.
Giusti-Rodríguez, P.
Hanscombe, K.B.
Adan, R.A.H.
Alfredsson, L.
Ando, T.
Andreassen, O.A.
Berrettini, W.H.
Boehm, I.
Boni, C.
Boraska Perica, V.
Buehren, K.
Burghardt, R.
Cassina, M.
Cichon, S.
Clementi, M.
Cone, R.D.
Courtet, P.
Crow, S.
Crowley, J.J.
Danner, U.N.
Davis, O.S.P.
de Zwaan, M.
Dedoussis, G.
Degortes, D.
DeSocio, J.E.
Dick, D.M.
Dikeos, D.
Dina, C.
Dmitrzak-Weglarz, M.
Docampo, E.
Duncan, L.E.
Egberts, K.
Ehrlich, S.
Escaramís, G.
Esko, T.
Estivill, X.
Farmer, A.
Favaro, A.
Fernández-Aranda, F.
Fichter, M.M.
Fischer, K.
Föcker, M.
Foretova, L.
Forstner, A.J.
Forzan, M.
Franklin, C.S.
Gallinger, S.
Giegling, I.
Giuranna, J.
Gonidakis, F.
Gorwood, P.
Gratacos Mayora, M.
Guillaume, S.
Guo, Y.
Hakonarson, H.
Hatzikotoulas, K.
Hauser, J.
Hebebrand, J.
Helder, S.G.
Herms, S.
Herpertz-Dahlmann, B.
Herzog, W.
Huckins, L.M.
Hudson, J.I.
Imgart, H.
Inoko, H.
Janout, V.
Jiménez-Murcia, S.
Julià, A.
Kalsi, G.
Kaminská, D.
Karhunen, L.
Karwautz, A.
Kas, M.J.H.
Kennedy, J.L.
Keski-Rahkonen, A.
Kiezebrink, K.
Kim, Y.-R.
Klump, K.L.
Knudsen, G.P.S.
La Via, M.C.
Le Hellard, S.
Levitan, R.D.
Li, D.
Lilenfeld, L.
Lin, B.D.
Lissowska, J.
Luykx, J.
Magistretti, P.J.
Maj, M.
Mannik, K.
Marsal, S.
Marshall, C.R.
Mattingsdal, M.
McDevitt, S.
McGuffin, P.
Metspalu, A.
Meulenbelt, I.
Micali, N.
Mitchell, K.
Monteleone, A.M.
Monteleone, P.
Nacmias, B.
Navratilova, M.
Ntalla, I.
O'Toole, J.K.
Ophoff, R.A.
Padyukov, L.
Palotie, A.
Pantel, J.
Papezova, H.
Pinto, D.
Rabionet, R.
Raevuori, A.
Ramoz, N.
Reichborn-Kjennerud, T.
Ricca, V.
Ripatti, S.
Ritschel, F.
Roberts, M.
Rotondo, A.
Rujescu, D.
Rybakowski, F.
Santonastaso, P.
Scherag, A.
Scherer, S.W.
Schmidt, U.
Schork, N.J.
Schosser, A.
Seitz, J.
Slachtova, L.
Slagboom, P.E.
Slof-Op't Landt, M.C.T.
Slopien, A.
Sorbi, S.
Świątkowska, B.
Szatkiewicz, J.P.
Tachmazidou, I.
Tenconi, E.
Tortorella, A.
Tozzi, F.
Treasure, J.
Tsitsika, A.
Tyszkiewicz-Nwafor, M.
Tziouvas, K.
van Elburg, A.A.
van Furth, E.F.
Wagner, G.
Walton, E.
Widen, E.
Zeggini, E.
Zerwas, S.
Zipfel, S.
Bergen, A.W.
Boden, J.M.
Brandt, H.
Crawford, S.
Halmi, K.A.
Horwood, L.J.
Johnson, C.
Kaplan, A.S.
Kaye, W.H.
Mitchell, J.
Olsen, C.M.
Pearson, J.F.
Pedersen, N.L.
Strober, M.
Werge, T.
Whiteman, D.C.
Woodside, D.B.
Grove, J.
Henders, A.K.
Larsen, J.T.
Parker, R.
Petersen, L.V.
Jordan, J.
Kennedy, M.A.
Birgegård, A.
Lichtenstein, P.
Norring, C.
Landén, M.
Mortensen, P.B.
Polimanti, R.
McClintick, J.N.
Adkins, A.E.
Aliev, F.
Bacanu, S.-A.
Batzler, A.
Bertelsen, S.
Biernacka, J.M.
Bigdeli, T.B.
Chen, L.-S.
Clarke, T.-K.
Degenhardt, F.
Docherty, A.R.
Edwards, A.C.
Foo, J.C.
Fox, L.
Frank, J.
Hack, L.M.
Hartmann, A.M.
Hartz, S.M.
Heilmann-Heimbach, S.
Hodgkinson, C.
Hoffmann, P.
Hottenga, J.-J.
Konte, B.
Lahti, J.
Lahti-Pulkkinen, M.
Lai, D.
Ligthart, L.
Loukola, A.
Maher, B.S.
Mbarek, H.
McIntosh, A.M.
McQueen, M.B.
Meyers, J.L.
Milaneschi, Y.
Palviainen, T.
Peterson, R.E.
Ryu, E.
Saccone, N.L.
Salvatore, J.E.
Sanchez-Roige, S.
Schwandt, M.
Sherva, R.
Streit, F.
Strohmaier, J.
Thomas, N.
Wang, J.-C.
Webb, B.T.
Wedow, R.
Wetherill, L.
Wills, A.G.
Zhou, H.
Boardman, J.D.
Chen, D.
Choi, D.-S.
Copeland, W.E.
Culverhouse, R.C.
Dahmen, N.
Degenhardt, L.
Domingue, B.W.
Frye, M.A.
Gäebel, W.
Hayward, C.
Ising, M.
Keyes, M.
Kiefer, F.
Koller, G.
Kramer, J.
Kuperman, S.
Lucae, S.
Lynskey, M.T.
Maier, W.
Mann, K.
Männistö, S.
Müller-Myhsok, B.
Murray, A.D.
Nurnberger, J.I.
Preuss, U.
Räikkönen, K.
Reynolds, M.D.
Ridinger, M.
Scherbaum, N.
Schuckit, M.A.
Soyka, M.
Treutlein, J.
Witt, S.H.
Wodarz, N.
Zill, P.
Adkins, D.E.
Boomsma, D.I.
Bierut, L.J.
Brown, S.A.
Bucholz, K.K.
Costello, E.J.
de Wit, H.
Diazgranados, N.
Eriksson, J.G.
Farrer, L.A.
Foroud, T.M.
Gillespie, N.A.
Goate, A.M.
Goldman, D.
Grucza, R.A.
Hancock, D.B.
Harris, K.M.
Hesselbrock, V.
Hewitt, J.K.
Hopfer, C.J.
Iacono, W.G.
Johnson, E.O.
Karpyak, V.M.
Kendler, K.S.
Kranzler, H.R.
Krauter, K.
Lind, P.A.
McGue, M.
MacKillop, J.
Madden, P.A.F.
Maes, H.H.
Magnusson, P.K.E.
Nelson, E.C.
Nöthen, M.M.
Palmer, A.A.
Penninx, B.W.J.H.
Porjesz, B.
Rice, J.P.
Rietschel, M.
Riley, B.P.
Rose, R.J.
Shen, P.-H.
Silberg, J.
Stallings, M.C.
Tarter, R.E.
Vanyukov, M.M.
Vrieze, S.
Wall, T.L.
Whitfield, J.B.
Zhao, H.
Neale, B.M.
Wade, T.D.
Heath, A.C.
Montgomery, G.W.
Martin, N.G.
Sullivan, P.F.
Kaprio, J.
Breen, G.
Gelernter, J.
Edenberg, H.J.
Bulik, C.M.
Agrawal, A.

Addiction Biology

Wiley-Blackwell Publishing Ltd

26

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alcoholism; anorexia nervosa; Article; binge eating disorder; bulimia; cannabis addiction; cannabis use; controlled study; drug dependence; eating disorder; gene linkage disequilibrium; gene locus; genetic association; genetic correlation; genetic risk; genome-wide association study; human; major clinical study; major depression; phenotype; priority journal; regression analysis; sample size; schizophrenia; single nucleotide polymorphism; smoking; tobacco dependence; drug dependence; eating disorder; genetics; phenotype; risk factor, Alcoholism; Depressive Disorder, Major; Feeding and Eating Disorders; Genome-Wide Association Study; Humans; Linkage Disequilibrium; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Schizophrenia; Substance-Related Disorders; Tobacco Use Disorder

https://doi.org/10.1111/adb.12880

10.1111/adb.12880

https://pergamos.lib.uoa.gr/uoa/dl/object/3020596