Τίτλος:
Characterization and biological evaluation of propolis from Poland
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In this study, we assessed the therapeutic potential of propolis from Poland and performed chemical analysis by GC-MS, as well as determined its botanical origin. Chemical constituents typical for bud exudates of Populus nigra (section Aigeiros) were determined, however, glycerol esters of phenolic acids, as well as unusually high amounts of p-coumaric and ferulic acid and their benzyl esters, were also detected. These constituents are characteristic for buds of Populus tremula (section Leuce). We also evaluated the antiproliferative effect of propolis extracts against nine human cancer cell lines. Additionally, promising antibacterial activity of the dichloromethane extract (Minimal Inhibitory Concentration MIC values of 0.95-1.24 mg/mL), as well as a moderate antifungal activity (MIC values of 1.25-1.40 mg/mL), was noticed. Propolis from Poland appeared as a rich source of antibacterial and antiproliferative compounds and this confirmed that it is a valuable natural product with the potential to improve human health. © 2017 by the authors.
Συγγραφείς:
Popova, M.
Giannopoulou, E.
Skalicka-Wózniak, K.
Graikou, K.
Widelski, J.
Bankova, V.
Kalofonos, H.
Sivolapenko, G.
Gaweł-Bȩben, K.
Antosiewicz, B.
Chinou, I.
Περιοδικό:
Molecules (Basel, Switzerland)
Λέξεις-κλειδιά:
antifungal agent; antiinfective agent; antineoplastic agent; coumaric acid; ferulic acid; hydroxybenzoic acid derivative; phenolic acid; propolis, chemistry; human; mass fragmentography; Poland; tumor cell line, Anti-Bacterial Agents; Antifungal Agents; Antineoplastic Agents; Cell Line, Tumor; Coumaric Acids; Gas Chromatography-Mass Spectrometry; Humans; Hydroxybenzoates; Poland; Propolis
DOI:
10.3390/molecules22071159
