Τίτλος:
The strength in numbers: comprehensive characterization of house dust using complementary mass spectrometric techniques
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Untargeted analysis of a composite house dust sample has been performed as part of a collaborative effort to evaluate the progress in the field of suspect and nontarget screening and build an extensive database of organic indoor environment contaminants. Twenty-one participants reported results that were curated by the organizers of the collaborative trial. In total, nearly 2350 compounds were identified (18%) or tentatively identified (25% at confidence level 2 and 58% at confidence level 3), making the collaborative trial a success. However, a relatively small share (37%) of all compounds were reported by more than one participant, which shows that there is plenty of room for improvement in the field of suspect and nontarget screening. An even a smaller share (5%) of the total number of compounds were detected using both liquid chromatography–mass spectrometry (LC-MS) and gas chromatography–mass spectrometry (GC-MS). Thus, the two MS techniques are highly complementary. Most of the compounds were detected using LC with electrospray ionization (ESI) MS and comprehensive 2D GC (GC×GC) with atmospheric pressure chemical ionization (APCI) and electron ionization (EI), respectively. Collectively, the three techniques accounted for more than 75% of the reported compounds. Glycols, pharmaceuticals, pesticides, and various biogenic compounds dominated among the compounds reported by LC-MS participants, while hydrocarbons, hydrocarbon derivatives, and chlorinated paraffins and chlorinated biphenyls were primarily reported by GC-MS participants. Plastics additives, flavor and fragrances, and personal care products were reported by both LC-MS and GC-MS participants. It was concluded that the use of multiple analytical techniques was required for a comprehensive characterization of house dust contaminants. Further, several recommendations are given for improved suspect and nontarget screening of house dust and other indoor environment samples, including the use of open-source data processing tools. One of the tools allowed provisional identification of almost 500 compounds that had not been reported by participants. [Figure not available: see fulltext.]. © 2019, The Author(s).
Συγγραφείς:
Rostkowski, P.
Haglund, P.
Aalizadeh, R.
Alygizakis, N.
Thomaidis, N.
Arandes, J.B.
Nizzetto, P.B.
Booij, P.
Budzinski, H.
Brunswick, P.
Covaci, A.
Gallampois, C.
Grosse, S.
Hindle, R.
Ipolyi, I.
Jobst, K.
Kaserzon, S.L.
Leonards, P.
Lestremau, F.
Letzel, T.
Magnér, J.
Matsukami, H.
Moschet, C.
Oswald, P.
Plassmann, M.
Slobodnik, J.
Yang, C.
Περιοδικό:
Analytical and Bioanalytical Chemistry
Λέξεις-κλειδιά:
Atmospheric ionization; Atmospheric pressure; Data handling; Distributed computer systems; Electrospray ionization; Fragrances; Gas chromatography; Houses; Hydrocarbon refining; Hydrocarbons; Liquid chromatography; Mass spectrometry; Screening, Atmospheric pressure chemical ionization; Collaborative trial; Complementary analytical techniques; Electrospray ionization (ESI); House dust; Non-target analysis; Personal care products; Spectrometric techniques, Dust
DOI:
10.1007/s00216-019-01615-6
