Τίτλος:
Sex differences in ambulatory blood pressure levels, control, and
phenotypes of hypertension in kidney transplant recipients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: Ambulatory blood pressure (BP) control is worse in men
compared with women with chronic kidney disease (CKD) and this may
partially explain the faster CKD progression in men. This is the first
study investigating possible sex differences in prevalence, control and
phenotypes of hypertension in kidney transplant recipients (KTRs) with
office-BP and 24-h ambulatory BP monitoring (ABPM). Methods: This
cross-sectional study included 136 male and 69 female stable KTRs who
underwent office-BP measurements and 24-h ABPM. Hypertension thresholds
for office and ambulatory BP were defined according to the 2017 ACC/AHA
and 2021 KDIGO guidelines for KTRs. Results: Age, time from
transplantation, eGFR and history of major comorbidities did not differ
between groups. Office SBP/DBP levels were insignificantly higher in men
than women (130.3 +/- 16.3/77.3 +/- 9.4 vs. 126.4 +/- 17.8/74.9 +/- 11.5
mmHg; P = 0.118/0.104) but daytime SBP/DBP was significantly higher in
men (128.5 +/- 12.1/83.0 +/- 8.2 vs. 124.6 +/- 11.9/80.3 +/- 9.3 mmHg; P
= 0.032/P = 0.044). No significant between-group differences were
detected for night-time BP. The prevalence of hypertension was similar
by office-BP criteria (93.4 vs. 91.3%; P = 0.589), but higher in men
than women with ABPM (100 vs. 95.7%; P = 0.014). The use of ACEIs/ARBs
and CCBs was more common in men. Office-BP control was similar (43.3 vs.
44.4%, P = 0.882), but 24-h control was significantly lower in men than
women (16.9 vs. 30.3%; P = 0.029). White-coat hypertension was similar
(5.1 vs. 7.6%; P = 0.493), whereas masked hypertension was
insignificantly more prevalent in men than women (35.3 vs. 24.2%; P =
0.113). Conclusion: BP levels, hypertension prevalence and control are
similar by office criteria but significantly different by ABPM criteria
between male and female KTRs. Worse ambulatory BP control in male
compared with female KTRs may interfere with renal and cardiovascular
outcomes.
Συγγραφείς:
Korogiannou, Maria
Sarafidis, Pantelis
Theodorakopoulou, Marieta
P.
Alexandrou, Maria Eleni
Xagas, Efstathios
Argyris,
Antonis
Protogerou, Athanase
Ferro, Charles J.
Boletis,
Ioannis N.
Marinaki, Smaragdi
Περιοδικό:
JOURNAL OF HYPERTENSION
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
ambulatory blood pressure; control; kidney transplantation; office blood
pressure; prevalence
DOI:
10.1097/HJH.0000000000003019
