Τίτλος:
DEXAMETHASONE THERAPY FOR BACTERIAL-MENINGITIS IN CHILDREN - 2-DAY
VERSUS 4-DAY REGIMEN
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Four-day dexamethasone therapy has been used to treat bacterial
meningitis. This prospective, randomized study compared the effect of a
2-day versus a 4-day regimen. Children (n = 118, ages 2.5 months to 15
years) were evaluated; 50% of the cases were due to Neisseria
meningitidis and 40% to Haemophilus influenzae type b. Patients were
treated intravenously (iv) mainly with conventional antimicrobial
therapy and were randomly assigned to receive dexamethasone, 0.15 mg/kg
iv every 6 h for 2 or 4 days. The clinical response was similar for both
dexamethasone regimens. The meningococcal meningitis patients survived
without neurologic or audiologic sequelae. On long-term follow-up,
neurologic sequelae or moderate or more severe unilateral or bilateral
hearing impairment (or both) were found in 1.8% and 3.8% of patients
treated with dexamethasone for 2 and 4 days, respectively. The 2-day
regimen appears appropriate for the treatment of H. influenzae and
meningococcal meningitis.
Συγγραφείς:
SYROGIANNOPOULOS, GA
LOURIDA, AN
THEODORIDOU, MC
PAPPAS, IG
and BABILIS, GC
ECONOMIDIS, JJ
ZOUMBOULAKIS, DJ
BERATIS, NG
and MATSANIOTIS, NS
Περιοδικό:
JOURNAL OF INFECTIOUS DISEASES
Εκδότης:
University of Chicago Press
DOI:
10.1093/infdis/169.4.853
