Τίτλος:
INHIBITION OF ANGIOGENESIS, TUMOR-GROWTH AND METASTASIS BY THE
NO-RELEASING VASODILATORS, ISOSORBIDE MONONITRATE AND DINITRATE
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
1 The effect of the nitric oxide (NO)-producing nitrovasodilators
isosorbide mononitrate (ISMN) and isosorbide dinitrate (ISDN) were
assessed on (a) the in vivo model of angiogenesis of the chick
chorioallantoic membrane (CAM) and (b) on the growth and metastatic
properties of the Lewis Lung carcinoma (LLC) in mice.
2 Isosorbide 5-mononitrate (ISMN) and isosorbide dinitrate (ISDN),
inhibited angiogenesis in the CAM dose-dependently. ISMN was more potent
in inhibiting this process. Both compounds were capable of completely
reversing the angiogenic effect of alpha-thrombin. These effects of ISMN
and ISDN on angiogenesis were comparable to those previously observed
with sodium nitroprusside which generates NO non-enzymatically.
3 Mice, implanted intramuscularly with LLC, received daily i.p.
injections of ISMN for 14 days resulting in a significant decrease in
the size of the primary tumour and a reduction in the number and size of
metastatic foci in the lungs. ISDN had a similar but less pronounced
effect than that observed with ISMN.
4 Addition of ISMN or ISDN to cultures of bovine, rabbit and human
endothelial cells and to cultures of LLC cells had no effect on their
growth characteristics.
5 These results indicate that ISMN and ISDN inhibit angiogenesis and
tumour growth and metastasis in an animal tumour model. The possibility
should therefore be considered that these nitrovasodilators which are
widely used therapeutically and have well characterized pharmacological
profiles, may also possess antitumour properties in the clinic.
Συγγραφείς:
PIPILISYNETOS, E
PAPAGEORGIOU, A
SAKKOULA, E
SOTIROPOULOU, G
and FOTSIS, T
KARAKIULAKIS, G
MARAGOUDAKIS, ME
Περιοδικό:
British Journal of Pharmacology
Λέξεις-κλειδιά:
ISOSORBIDE 5-MONONITRATE; ISOSORBIDE DINITRATE; NITRIC OXIDE;
VASODILATORS; TUMOR GROWTH; METASTASIS; ANGIOGENESIS
DOI:
10.1111/j.1476-5381.1995.tb16670.x
