Τίτλος:
Acute promyelocytic leukemia relapsing into FAB-M2 acute myeloid
leukemia with trisomy 8
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Acute promyelocytic leukemia was diagnosed in a 48-year-old man; the
karyotype was normal, whereas reverse transcriptase polymerase chain
reaction (RT-PCR) analysis identified PML/RAR alpha chimeric transcripts
of the bcr3 type. Rather unexpectedly, the patient did not respond to
all-trans retinoic acid administration; he attained complete remission
with conventional chemotherapy and became PML/RAR alpha negative. Two
years later while PML/RAR alpha negative nn RT-PCR he presented with
thrombocytopenia. Bone marrow examination was compatible with
myelodysplasia of the RAEB type; the karyotype was normal. Then, after
10 months, he developed overt acute myeloid leukemia with PML/RAR alpha
negative, French-American-British MZ blasts; karyotypic analysis
revealed mosaicism for trisomy 8. (C) Elsevier Science Inc., 2000. All
rights reserved.
Συγγραφείς:
Stavroyianni, N
Yataganas, X
Abazis, D
Pangalos, C and
Meletis, J
Περιοδικό:
CANCER GENETICS AND CYTOGENETICS
Εκδότης:
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI:
10.1016/S0165-4608(99)00132-6
