Περίληψη:
Insertion (I)/deletion (D) polymorphism of the ACE gene has been
reported to be involved in various cardiovascular diseases. We
investigated prospectively whether the response to the ACE inhibitor
fosinopril varied according to the ACE genotype in previously untreated
Creek hypertensive patients. After a 4-week observation period,
fosinopril was administered at a dose of 20 mg daily and blood pressure
was measured weekly for 6 months. The study population consisted of 104
hypertensive patients (46 male, 58 female). There were no differences in
age, gender, body mass index, and pretreatment blood pressure levels
among patients with the DD, ID, and II genotypes (n = 42, 30, 32,
respectively). The reduction in systolic blood pressure was
significantly greater in patients carrying the DD compared to II or ID
genotypes (5.6 +/- 3.1 vs. 3.1 +/- 1.1 or 3.6 +/- 2.2, respectively;
ANOVA, p < 0.05). The reduction in diastolic blood pressure was also
significantly greater in DD hypertensives compared with II or ID (8.9
+/- 6 vs. 5.5 +/- 3.4 or 5.8 +/- 4, respectively; ANOVA, p < 0.05). The
age and BMI were not correlated with the changes in SEP or DBP that were
observed after fosinopril administration. In conclusion, the ACE gene
genotype was shown to influence the response to fosinopril in
hypertensive patients.
Συγγραφείς:
Stavroulakis, GA
Makris, TK
Krespi, PG
Hatzizacharias, AN
and Gialeraki, AE
Anastasiadis, G
Triposkiadis, P and
Kyriakidis, M
