Τίτλος:
Liposomal forms of anticancer agents beyond anthracyclines: Present and future perspectives
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Liposomes are widely used as delivery systems of cytotoxic drugs. The encapsulation into liposomes improves pharmacological properties and as a result therapeutic index and outcomes. To date, liposomal vincristine and cytarabine are approved and marketed for intravenous and intrathecal administration, respectively. The main goal of this review is to examine the clinical use and pharmacological properties, as well as the safety of liposomal forms of less widely used liposomal forms of anticancer agents compared to their conventional forms and to present data regarding clinical development of other liposomal agents. Liposomal forms of cytarabine and vincristine are less widely used and unknown compared to liposomal anthracyclines, because they are approved only for specific indications and only in the United States. © 2014 Informa Healthcare USA, Inc.
Συγγραφείς:
Papachristos, A.
Pippa, N.
Ioannidis, K.
Sivolapenko, G.
Demetzos, C.
Περιοδικό:
Journal of Liposome Research
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
anthracycline; antineoplastic agent; cisplatin; cytarabine; cytarabine plus daunorubicin; firtecan; liposome; methotrexate; navelbine; paclitaxel; platinum 1,2 diaminocyclohexane bisneodecanoate; retinoic acid; vincristine; vincristine sulfate; anthracycline; antineoplastic agent; liposome; pharmacological biomarker, antineoplastic activity; area under the curve; circulation time; cytotoxicity; drug blood level; drug efficacy; drug formulation; drug half life; drug indication; drug mechanism; drug safety; drug urine level; elimination half-life; encapsulation; human; nonhuman; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); phospholipid bilayer; plasma clearance; priority journal; Review; systematic review; United States; animal; chemistry; drug delivery system, Animals; Anthracyclines; Antineoplastic Agents; Biomarkers, Pharmacological; Drug Delivery Systems; Humans; Liposomes
DOI:
10.3109/08982104.2014.950277
