Τίτλος:
The role of renal nerve ablation for the management of resistant hypertension and other disease conditions: Benefits and concerns
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The sympathetic nervous system is overactivated in resistant hypertension and several other disease conditions. A reciprocal association between the brain and the kidney has been described, in that sympathetic overactivity affects renal function while renal injury stimulates central sympathetic drive. Renal nerve ablation has been recently introduced as a potential alternative for the management of resistant hypertension, mainly due to current limitations in pharmacologic antihypertensive therapy. Data accumulated thus far point towards an efficacious and safe interventional method for the management of treatment resistance, with additional benefits on glucose metabolism and cardiac structure and function. Furthermore, beneficial effects have been observed in patients with chronic kidney disease, obstructive sleep apnea, polycystic ovary syndrome, and sympathetically driven tachyarrhythmias. However, as with every novel technique, several questions need to be answered and concerns need to be addressed before the wide application of this interventional approach.© 2014 Bentham Science Publishers.
Συγγραφείς:
Faselis, C.
Doumas, M.
Kokkinos, P.
Tsioufis, C.
Papademetriou, V.
Περιοδικό:
Current Vascular Pharmacology
Εκδότης:
Bentham Science Publishers
Λέξεις-κλειδιά:
anxiolytic agent; darusentan; opiate; spironolactone, ablation therapy; adrenergic system; antihypertensive therapy; artery catheterization; artery occlusion; article; blood clotting; blood pressure monitoring; blood pressure variability; cardiovascular mortality; chronic kidney disease; heart disease; human; hypotension; kidney denervation; kidney function; kidney injury; lifestyle modification; meta analysis (topic); nerve injury; nonhuman; ovary polycystic disease; randomized controlled trial (topic); renal nerve ablation; resistant hypertension; sleep disordered breathing; tachycardia, Catheter Ablation; Disease Management; Drug Resistance; Humans; Hypertension; Kidney; Randomized Controlled Trials as Topic; Sympathectomy; Sympathetic Nervous System; Treatment Outcome
DOI:
10.2174/15701611113119990139
