Περίληψη:
Introduction: Obesity in childhood and adolescence is associated with complications that resemble those seen in hypercortisolism. Hair cortisol concentration (HCC) in children is a reliable marker of long-term endogenous cortisol concentrations. We determined HCC in overweight and obese children and adolescents, and examined the relation between HCC and other cardiometabolic parameters. Methods: Three hundred children and adolescents aged 4-18 years (mean age ± standard error of the mean [SEM]: 10.49 ± 0.15 years; 140 [46.7%] obese, 94 [31.3%] overweight, 66 [22%] of normal BMI; 76 males, 224 females) were studied prospectively. Blood samples for determination of hematological, biochemical, and endocrinologic parameters were obtained. Systolic (SBP) and diastolic blood pressure (DBP) was determined. Scalp hair samples were collected from the posterior vertex, and HCC was measured using an electrochemiluminescence immunoassay. Results: Obese subjects had significantly higher SBP, DBP, waist and hip circumferences, waist-to-hip ratio, waist-to-height ratio, ALT, γ-GT, triglycerides, apolipoprotein-B, insulin, and HbA1C concentrations than overweight and normal-BMI subjects. HCC did not differ significantly among the three groups of subjects (mean ± SEM: 8.74 ± 0.43 vs. 8.88 ± 0.52 vs. 9.33 ± 0.72, all p > 0.05). No significant association was noted between HCC and cardiometabolic or body composition parameters. HCC was significantly higher in prepubertal girls than prepubertal boys (9.45 ± 0.38 vs. 7.35 ± 0.39, p = 0.007). Conclusion: In our study, overweight and obesity was not associated with elevated HCC. Furthermore, no association was found between HCC with cardiometabolic parameters and fat mass. Further studies are required to delineate the association between overweight/obesity and HCC. © 2019 S. Karger AG, Basel. Copyright: All rights reserved.
Συγγραφείς:
Genitsaridi, S.-M.
Karampatsou, S.
Papageorgiou, I.
Mantzou, A.
Papathanasiou, C.
Kassari, P.
Paltoglou, G.
Kourkouti, C.
Charmandari, E.
Λέξεις-κλειδιά:
25 hydroxyergocalciferol; apolipoprotein A; apolipoprotein B; corticotropin; gamma glutamyltransferase; hemoglobin A1c; high density lipoprotein cholesterol; hydrocortisone; lipoprotein; somatomedin binding protein 3; somatomedin C; thyroglobulin antibody; thyroid peroxidase antibody; thyrotropin; hydrocortisone, adolescent; adult; Article; aspartate aminotransferase level; basal metabolic rate; biochemical analysis; body mass; bone mass; cardiometabolic risk; chemiluminescence immunoassay; child; cohort analysis; controlled study; cross-sectional study; electrochemiluminescence; fat mass; female; free thyroxine index; glucose blood level; hair analysis; hair level; hematological parameters; high performance liquid chromatography; homeostasis model assessment; human; hypercortisolism; major clinical study; male; muscle mass; obesity; priority journal; prospective study; Quantitative Insulin Sensitivity Check Index; scalp hair; systolic blood pressure; total body water; total cholesterol level; waist circumference; waist hip ratio; waist to height ratio; blood pressure; body composition; chemistry; childhood obesity; hair; obesity; pathophysiology; physiology; preschool child, Adolescent; Blood Pressure; Body Composition; Body Mass Index; Child; Child, Preschool; Female; Hair; Humans; Hydrocortisone; Male; Overweight; Pediatric Obesity
