Τίτλος:
Ιmpact of sunitinib-induced hypothyroidism on survival of patients with metastatic renal cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Sunitinib plays an important role in managing the metastatic renal cell cancer (mRCC). Sunitinib-induced hypothyroidism is a common side-effect of the drug. There have been attempts to link hypothyroidism with a better clinical outcome in sunitinib-treated (mRCC) patients. Our aim was to relate the impact of hypothyroidism to the survival of these patients. Methods: We have evaluated 70 patients with mRCC that received sunitinib as a first line treatment. Thyroid-stimulating hormone (TSH) was measured at baseline, after 15 days of treatment (day-15) and at the end of the second cycle (day-75). Biomarker data and correlations with response were analysed with Microsoft Excel. Comparison results from Student's t-test with a p less than 0.05 were considered statistically significant. Kaplan-Meyer and log-rank tests were performed using GraphPad Prism 5 for Windows. Results: Regarding the response to treatment, a progression-free survival (PFS) of 9.47 months and an overall survival (OS) of 22.03 months were demonstrated. Our data are consistent with published data by other authors. On day-15 from the beginning of the treatment an important number of patients exhibited a TSH elevation. On day-15 42.86% had a TSH over the upper normal limit and 50.0% at the end of the second cycle (day-75). TSH increased earlier in patients that exhibited an objective response (× 3.33 times the baseline values on day-15) than patients that exhibited disease stabilisation (× 2.18) or disease progression (× 1.59). Early increases in TSH were associated with a longer PFS (11.92 vs. 8.82 months, p = 0.0476) and a longer OS (3.10 vs. 1.08 years, p = 0.0011). Conclusions: Early TSH-increase is associated with a clinical benefit. The patients that showed at least a twofold increase of their baseline TSH, responded to therapy by stabilisation or by regression of disease. This is the only study to our knowledge which shows that early increases-2 weeks from starting the treatment-in TSH levels have a prognostic value. Both PFS and OS of the patients who demonstrated a higher than a twofold rise were significantly longer than the PFS and the OS of the patients that presented a lower or no TSH-increase. © 2019 The Author(s).
Συγγραφείς:
Vasileiadis, T.
Chrisofos, M.
Safioleas, M.
Kontzoglou, K.
Papazisis, K.
Sdrolia, A.
Εκδότης:
BioMed Central Ltd.
Λέξεις-κλειδιά:
sunitinib; thyrotropin; antineoplastic agent; sunitinib; thyrotropin, adult; aged; Article; cancer patient; cancer survival; controlled study; data analysis software; disease course; drug dose reduction; female; human; hypothyroidism; Kaplan Meier method; kidney metastasis; log rank test; major clinical study; male; multiple cycle treatment; overall survival; progression free survival; Student t test; thyrotropin blood level; treatment duration; treatment outcome; treatment response; very elderly; chemically induced; disease free survival; drug administration; hypothyroidism; kidney tumor; metabolism; middle aged; mortality; prognosis; renal cell carcinoma; retrospective study, Adult; Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Hypothyroidism; Kaplan-Meier Estimate; Kidney Neoplasms; Male; Middle Aged; Prognosis; Retrospective Studies; Sunitinib; Thyrotropin; Treatment Outcome
DOI:
10.1186/s12885-019-5610-8
