Τίτλος:
Glucose‐6‐phosphate dehydrogenase, colour vision and Xg blood groups in Greece: linkage and population data
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
1. The same recombination frequency (26 %) between the loci for G‐6‐PD and Xg was found in Greek populations as had been found in Israelis. Prof. Siniscalco's data from Sardinia do not agree with this frequency. 2. In four Greek populations sampled there is no correlation between the frequency of colour blindness and of G‐6‐PD deficiency. Furthermore, there is no evidence of an excess of X chromosomes bearing both abnormal genes in coupling in Greece. In both these respects the Greeks differ from the Sardinians. 3. It is possible that the discrepancies between Greeks and Israelis on the one hand and Sardinians on the other are due, as Prof. Siniscalco has suggested, to a high prevalence in Sardinia of an abnormal chromosomal rearrangement such as an inversion. 4. No recombination between the loci for G‐6‐PD and colour vision was found in four sibships. We are grateful to Prof. C. Choremis, Dr P. Fessas, Dr E. R. Giblett, Prof. A. G. Motulsky and Dr L. Zannos‐Mariolea for encouragement and advice. We also thank the following for help at various stages of the investigation: Dr N. Votetsianos of Karditsa, Dr G. Rizos of Arta, Dr E. Gavriilidou, Dr E. Tjartjoura and Dr E. Tzingos of Athens, Mrs N. Keil, Mrs N. Morrow and Mrs L. Steinmann of Seattle, Miss J. Gavin and Dr P. Tippett of London. This study was partially supported by U.S. Public Health Service Grant H. 3091. Copyright © 1963, Wiley Blackwell. All rights reserved
Συγγραφείς:
FRASER, G.R.
DEFARANAS, B.
KATTAMIS, C.A.
RACE, R.R.
SANGER, R.
STAMATOYANNOPOULOS, G.
Περιοδικό:
Annals of Human Genetics
Λέξεις-κλειδιά:
blood group antigen, article; blood group; chromosome; color blindness; color vision defect; GENETICS, HUMAN; glucose 6 phosphate dehydrogenase deficiency; GLUCOSEPHOSPHATE DEHY- DROGENASE DEFICIENCY; Greece; medical genetics; statistics, BLOOD GROUPS; CHROMOSOMES; COLOR BLINDNESS; GENETICS, HUMAN; GLUCOSEPHOSPHATE DEHY- DROGENASE DEFICIENCY; GREECE; STATISTICS, Blood Group Antigens; Chromosomes; Color Vision Defects; Genetics, Medical; Glucosephosphate Dehydrogenase Deficiency; Greece; Statistics as Topic
DOI:
10.1111/j.1469-1809.1963.tb01536.x
