Τίτλος:
High plasma amylin/islet amyloid polypeptide levels in patients with
residual medullary thyroid carcinoma after total thyroidectomy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: We have previously reported that amylin/islet amyloid
polypeptide (IAPP) mRNA is detected in a substantial subset of medullary
carcinomas of the thyroid (MTCs). The aim of this study was to determine
if the amylin/IAPP gene is expressed as the IAPP peptide in MTC tissues.
Design and Methods: In 10 patients with a histological diagnosis of MTC
and with persisting or recurrent disease (basal calcitonin levels > 250
pg/ml), the fasting serum insulin and plasma glucose, IAPP and
calcitonin levels were measured and compared with those of 18 normal
control subjects matched for age and body mass index. IAPP expression
was studied by immunohistochemistry in MTCs and lymph-node metastasis
tissues.
Results: Seven of ten MTC patients had abnormally elevated IAPP levels.
Plasma IAPP and serum insulin levels were correlated in both patients
and controls, but the slope of the regression line was significantly
higher for MTC patients. IAPP staining was detected in four out of 12
random MTC samples and in two out of five lymph-node metastases, using
immunohistochemistry.
Conclusions: These results indicate that MTC cells express IAPP at the
peptide level and that this raises the peripheral plasma levels. Further
studies may reveal whether this is a feature of malignant disease.
Συγγραφείς:
Alevizaki, M
Grigorakis, SI
Tseleni-Balafouta, S
Alevizaki,
CC
Philippou, G
Anastasiou, E
Souvatzoglou, A
Περιοδικό:
European Journal of Endocrinology
Εκδότης:
BIO SCIENTIFICA LTD
DOI:
10.1530/eje.0.1450585
