Τίτλος:
Clinical significance and biological role of HuR in head and neck carcinomas
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background. Hu-antigen R (HuR) is a posttranscriptional regulator of several target mRNAs, implicated in carcinogenesis. This review aims to present the current evidence regarding the biological role and potential clinical significance of HuR in head and neck carcinomas. Methods. The existing literature concerning HuR expression and function in head and neck carcinomas is critically presented and summarised. Results. HuR is expressed in the majority of the examined samples, showing higher cytoplasmic levels in malignant or premalignant cases. Moreover, HuR modulates several genes implicated in biological processes important for malignant transformation, growth, and invasiveness. HuR seems to be an adverse prognosticator in patients with OSCCs, whereas a correlation with a more aggressive phenotype is reported in several types of carcinomas. Conclusions. A consistent role of HuR in the carcinogenesis and progression of head and neck carcinomas is suggested; nevertheless, further studies are warranted to expand the present information. © 2018 Georgia Levidou et al.
Συγγραφείς:
Levidou, G.
Kotta-Loizou, I.
Tasoulas, J.
Papadopoulos, T.
Theocharis, S.
Περιοδικό:
Disease Markers
Λέξεις-κλειδιά:
ELAV like protein 1; ELAV like protein 1; ELAVL1 protein, human; tumor marker, cancer growth; clinical assessment; cytoplasm; enzyme activity; esophageal squamous cell carcinoma; evidence based practice; head and neck carcinoma; human; larynx squamous cell carcinoma; malignant transformation; mouth squamous cell carcinoma; nonhuman; physiological process; precancer; protein expression; protein function; Review; salivary gland tumor; thyroid gland; tumor invasion; gene expression regulation; gene regulatory network; genetics; head and neck tumor; metabolism; pathology; prognosis; upregulation, Biomarkers, Tumor; Cytoplasm; ELAV-Like Protein 1; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Head and Neck Neoplasms; Humans; Precancerous Conditions; Prognosis; Up-Regulation
DOI:
10.1155/2018/4020937
