Τίτλος:
Comparing calculated LDL-C with directly measured LDL-C in healthy and in dyslipidemic children
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background LDL-C is one of the strongest markers for atherosclerosis and therapeutic decisions in children are based on its levels. Friedewald formula (FF) which is usually used for the calculation of LDL-C (cLDL-C); and Anandaraja's formula (AF) may under- or overestimate actual levels. Objective To compare cLDL-C with directly measured LDL-C (dLDL-C) as a screening tool and to evaluate dyslipidemic children. Methods The study population consisted of 1005 children, 2–18 years, 688 of whom underwent lipid screening in a regular check-up (group A); and 317 were dyslipidemic (LDL-C ≥ 130 mg/dl) (group B). A fasting serum lipid profile was assessed. LDL-C was measured using a homogenous assay and was calculated using FF and AF. Results Each method of calculating LDL-C was highly correlated to dLDL-C. Using FF, cLDL-C was lower than dLDL-C in 75.6% (group A) and in 77.3% (group B) of children; the mean difference was significant in dyslipidemic group. Moreover, in group B, 25% of children with boundary high and 12% with high dLDL-C would be misclassified. Using AF, LDL-C was higher than dLDL-C; the mean difference was significant in group A. Based on cLDL-C, 52% of group A with borderline dLDL-C and 27.5% of group B children with boundary high dLDL-C would be considered as dyslipidemic and eligible for medication respectively. Conclusions Comparing two methods of calculated LDL-C with directly measured LDL-C. FF was more accurate as a screening tool while AF was more accurate in the evaluation and follow-up of the dyslipidemic group. © 2016 The Canadian Society of Clinical Chemists
Συγγραφείς:
Garoufi, A.
Drakatos, A.
Tsentidis, C.
Klinaki, E.
Paraskakis, I.
Marmarinos, A.
Gourgiotis, D.
Περιοδικό:
Clinical Biochemistry
Εκδότης:
W B SAUNDERS CO-ELSEVIER INC
Λέξεις-κλειδιά:
high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; low density lipoprotein, adolescent; adult; Article; autoanalyzer; calculation; child; cholesterol blood level; comparative study; controlled study; correlation analysis; diagnostic accuracy; diagnostic test accuracy study; diet restriction; dyslipidemia; evaluation and follow up; female; human; hypercholesterolemia; laboratory test; lipid analysis; major clinical study; male; medical examination; population; priority journal; screening; sensitivity and specificity; triacylglycerol blood level; blood; case control study; dyslipidemia; preschool child, Adolescent; Case-Control Studies; Child; Child, Preschool; Dyslipidemias; Female; Humans; Lipoproteins, LDL; Male
DOI:
10.1016/j.clinbiochem.2016.05.026
