Τίτλος:
Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: QT-wave abnormalities have been detected in type 1 diabetes mellitus (T1DM). Prolongation of the heart rate corrected QT interval (QTc) has been associated with cardiovascular mortality. We evaluated how often QT/QTc abnormalities are present in youth with T1DM and if they are associated with disease parameters. Methods: Sixty-two T1DM youngsters and equal age- and gender-matched controls were studied. Demographic, anthropometric, and laboratory data were determined. QT was measured on a 12-lead resting electrocardiogram. QTc was calculated using Bazett's formula. Results: T1DM patients had significantly longer QT/QTc than controls, but significance disappeared after adjustment for confounders. Abnormally prolonged QTc≥440 ms was observed six times more frequently in those with T1DM. QT was correlated with age, age at disease onset, but not with glycated hemoglobin or diabetes duration; QTc was only correlated with pubertal stage. Conclusions: T1DM youths have a sixfold increased risk for QT/QTc prolongation and should have regular follow-up for cardiac autonomic dysfunction. © 2014 by Walter de Gruyter Berlin Boston 2014.
Συγγραφείς:
Galli-Tsinopoulou, A.
Chatzidimitriou, A.
Kyrgios, I.
Rousso, I.
Varlamis, G.
Karavanaki, K.
Περιοδικό:
Journal of Pediatric Endocrinology and Metabolism
Εκδότης:
Freund Publishing House Ltd
Λέξεις-κλειδιά:
adolescent; adolescent disease; article; autonomic dysfunction; child; childhood disease; correlation analysis; electrocardiogram; female; follow up; human; insulin dependent diabetes mellitus; major clinical study; male; onset age; QT prolongation; risk assessment; sex difference, Child; Diabetes Mellitus, Type 1; Electrocardiography; Female; Heart; Humans; Male; Risk Factors; Young Adult
DOI:
10.1515/jpem-2013-0193
