Τίτλος:
Cellular HIV-1 DNA load predicts HIV-RNA rebound and the outcome of
highly active antiretroviral therapy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: To assess whether cellular HIV-1 DNA prior to highly active
antiretroviral therapy (HAART) initiation predicts its outcome.
Design and methods: Patients included all 51 hemophiliacs of the Greek
component of the Multicenter Hemophilia Cohort Study who had initiated
HAART and for whom cryopreserved lymphocyte samples before HAART
initiation were available. Cellular HIV-1 DNA quantification was
performed by a molecular beacon-based real-time PCR assay in multiple
samples per patient with a median (interquartile range) follow-up of 76
(45-102) weeks.
Results: The median (range) baseline HIV-1 DNA load was 297 (< 10 to
3468) copies per 1 x 10(6) peripheral blood mononuclear cells. Baseline
HIV-1 DNA load did not predict initial virological response (VR). None
of the patients with initial VR and baseline HIV-1 DNA load at or below
the median experienced a subsequent virological rebound, while the
cumulative probability of virological rebound by week 104 was 55% among
those with HIV-1 DNA load greater than the median (P<0.008). Cellular
HIV-1 DNA load was the only parameter associated with sustained
virological response as shown by univariate or multivariate analyses
[adjusted odds ratio (95% confidence interval) 0.197 (0.048-0.801)
per 1 log(10) increase in DNA copies, P = 0.023].
Conclusion: Low cellular HIV-1 DNA load is a marker of sustained
virological response in patients with initial VR and it can reliably
predict the long-term success of HAART. (C) 2004 Lippincott Williams
Wilkins.
Συγγραφείς:
Hatzakis, AE
Touloumi, G
Pantazis, N
Anastassopoulou, CG and
Katsarou, O
Karafoulidou, A
Goedert, JJ
Kostrikis, LG
Περιοδικό:
Ελληνικά Αρχεία AIDS=: Hellenic Archives of AIDS
Εκδότης:
Lippincott, Williams & Wilkins
Λέξεις-κλειδιά:
cellular HIV-1 DNA load; HIV-1 RNA rebound; antiretroviral therapy
DOI:
10.1097/00002030-200411190-00006
