Τίτλος:
Flow limitation and dynamic hyperinflation: key concepts in modern
respiratory physiology
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Fashions in ideas, like clothes, come and go. From approximately
1950-1980, physiological research was seen as the key discipline in
understanding lung disease and was at the cutting edge of pulmonary
science. Subsequently, its importance has been down played amid a widely
accepted but unfounded assumption that we now have a perfect working
understanding of the physiological behaviour of the respiratory system
in health and disease. Although it seems improbable that completely new
disciplines within respiratory physiology will emerge with fundamentally
different ways of describing the mechanical or gas exchanging function
of the lung, advances in computing and new observations in disease have
highlighted previously unsuspected physiological abnormalities that have
changed the way we view lung disease and the interface between
disordered lung mechanics, symptomatology and disability.
This is especially true for the two related physiological concepts of
expiratory flow limitation and dynamic hyperinflation, which are now
being taken from the physiological laboratory to the bedside with
dramatic effect. Each arises from well-established theoretical and
practical observations first made 40 yrs ago and now adapted to a range
of settings, particularly in the field of obstructive lung disease. This
review focuses on how these conditions are defined and assessed and what
evidence there is that they might be important in lung disease.
Συγγραφείς:
Calverley, PMA
Koulouris, NG
Περιοδικό:
European Respiratory Journal
Εκδότης:
EUROPEAN RESPIRATORY SOC JOURNALS LTD
Λέξεις-κλειδιά:
asthma; chronic obstructive pulmonary disease; exercise; flow
limitation; hyperinflation; physiological concepts
DOI:
10.1183/09031936.04.00113204
