Τίτλος:
Human herpesvirus-8 seropositivity and clinical correlations in
HIV-1-positive and highly exposed, persistently HIV-seronegative
individuals in Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The prevalence of anti-human herpesvirus 8 (HHV- 8) antibodies was
retrospectively assessed in a cohort of 248 consecutive HIV-1-positive
patients followed up in an academic unit in Greece during a 14-year
period and in 46 highly exposed, persistently HIV-seronegative (HEPS)
individuals. The impact of the initial anti-HHV-8 status on tumorgenesis
and mortality was studied. The first available serum sample from the
department’s pool was tested. Demographics and data regarding history of
sexually transmitted diseases, Hepatitis B surface antigen (HbsAg) and
hepatitis C (HCV) status were collected. Patients who developed either
HHV-8-related or non-HHV-8-related neoplasms during long-term follow-up
were also identified. Forty-eight percent of the HIV-1-positive patients
and 56% of the HEPS subjects were found anti-HHV-8-positive. No
difference was observed regarding the development of HHV-8-related or
non-HHV-8-related neoplasia and mortality on grounds of initial
anti-HHV- 8 status. Mortality was positively associated with the
presence of HBsAg. HCV infection showed a trend to be more common in
anti-HHV-8-positive patients. In summary, the seroprevalence of HHV-8
among HIV-1- positive patients is higher than the one reported in the
Western world. The initial anti-HHV-8 status is not a prognostic factor
in HIV-1- positive individuals. The high seroprevalence in HEPS
individuals possibly reflects their risk- prone lifestyle.
HbsAg-positive status is a long- term negative prognostic factor in HIV
infection.
Συγγραφείς:
Panayiotakopoulos, GD
Mavroyianni, D
Politou, M
Aroni, K and
Kosmopoulou, O
Kontos, AN
Choremi-Papadopoulou, H and
Pediaditis, J
Kordossis, T
Περιοδικό:
AIDS Patient Care and STDs
Εκδότης:
MARY ANN LIEBERT INC PUBL
DOI:
10.1089/apc.2005.19.375
