Περίληψη:
Background: The present study was designed to investigate the effects of
polycystic ovary syndrome (PCOS) and of obesity on serum parathyroid
hormone (PTH), 25-hydroxyvitamin D (25-OH-vitamin D), and
1,25-dihydroxyvitamin D [1,25-(OH)(2)-vitamin D] concentrations and
the possible associations of the above calciotropic hormones with the
hormonal and metabolic characteristics of the syndrome.
Methods: We studied 58 obese [body mass index (BMI) >30 kg/m(2)] women
with PCOS, 64 overweight (BMI, 25-30 kg/m(2)) women with the syndrome,
169 normalweight (BMI <25 kg/m(2)) women with PCOS, 29 obese controls
(ovulatory women without clinical or biochemical hyperandrogenemia), 14
overweight controls, and 70 normal-weight controls. Blood samples were
collected (at 0900 after an overnight fast) between the 3rd and 6th days
of a menstrual cycle in the control groups and during a spontaneous
bleeding episode in the PCOS groups. Circulating concentrations of
luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin
(PRL), testosterone, Delta 4-androstenedione, 17
alpha-hydroxyprogesterone, sex-hormone-binding globulin (SHBG), insulin,
glucose, PTH, 25-OH-vitamin D, and 1,25-(OH)(2)-vitamin D were measured.
Results: Both PCOS and increased body weight had a significant positive
effect on serum PTH values. PTH concentrations were significantly
correlated with age, BMI, glucose, PRL, SHBG, and testosterone. Only the
correlations with testosterone and PRL were BMI-independent. The effect
of PCOS on PTH concentrations remained significant after adjustment for
BMI, but not after adjustment for testosterone concentration. Increased
body weight also had a significant negative effect on 25-OH- and
1,25-(OH)(2)-vitamin D concentrations, but no association with the
syndrome was observed.
Conclusions: The results of the present study are in agreement with
previous data supporting an association of increased PTH and decreased
vitamin D metabolite concentrations with obesity. Moreover, the present
findings indicate, for the first time, that PTH probably is also linked
to PCOS-associated hyperandrogenism. (C) 2005 American Association for
Clinical Chemistry.
Συγγραφείς:
Panidis, D
Balaris, C
Farmakiotis, D
Rousso, D
Kourtis,
A
Balaris, V
Katsikis, I
Zournatzi, V and
Diamanti-Kandarakis, E
