Τίτλος:
Apolipoprotein E polymorphism is not associated with lipid levels and
coronary artery disease in Greek patients with familial
hypercholesterolaemia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Familial hypercholesterolaemia is a genetic disorder characterised by
high low-density lipoprotein (LDL) cholesterol concentrations, which
frequently gives rise to premature coronary artery disease (CAD). The
clinical expression of familial hypercholesterolaemia is highly variable
even in patients carrying the same LDL receptor gene mutation. This
variability may be due to environmental and other genetic factors.
Apolipoprotein E (Apo-E) has been extensively studied for its effects on
the phenotype of familial hypercholesterolaemia. In this study we
examined the influence of Apo-E genotype on lipid parameters and the
incidence of CAD in 93 Greek patients with familial
hypercholesterolaemia. Apo-E E2, E3 and E4 allele frequencies were 0.06,
0.86 and 0.09 respectively. The levels of total cholesterol, LDL
cholesterol, HDL cholesterol, triglycerides, apolipoproteins A and B and
lipoprotein alpha did not differ significantly among carriers and
non-carriers of the E4 allele. The prevalence of CAD and hypertension
did not differ either. Our results suggest that the E4 allele is not
associated with lipid levels or with the prevalence of CAD among
familial hypercholesterolaemia patients of the Greek population.
Συγγραφείς:
Pitsavos, C
Choumerianou, DM
Skoumas, J
Maumus, S and
Stefanadis, C
Dedoussis, GVZ
Visvikis-Siest, S
Περιοδικό:
Advances in Clinical and Experimental Medicine
Εκδότης:
SPRINGER-VERLAG ITALIA SRL
Λέξεις-κλειδιά:
apolipoprotein E; E4 allele; familial hypercholesterolaemia; lipids;
coronary artery disease
DOI:
10.1007/s10238-005-0086-z
