Τίτλος:
Pharmacokinetics of cefepime in bile and gall bladder tissue after
prophylactic administration in patients with extrahepatic biliary
diseases
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The purpose of this study was to determine the cefepime concentrations
in serum, bile and gall bladder tissue after administration of a single
dose in patients with extrahepatic biliary diseases for pre-operative
antimicrobial prophylaxis. During a 3-year period (1999-2002), 30
patients aged above 18 years with extrahepatic biliary diseases (acute
and chronic cholecystitis and symptomatic cholelithiasis) were included
in the study. Cefepime concentrations were determined by the agar
microbiological diffusion method. A significant correlation between
serum and gall bladder tissue concentrations of cefepime with the
sampling interval was observed (r(2) = 0.771, P < 0.0001), whereas no
correlation between serum and bile fluid concentrations of the drug was
noted. In patients with non-functioning gall bladder, very low tissue
levels of cefepime were detected. During the time of surgery, serum and
gall bladder tissue concentrations of cefepime exceeded the minimum
inhibitory concentration for 90% of the organisms (MIC90) for most
common pathogens. Cefepime has the required pharmacokinetic properties
to be considered for pre-operative antimicrobial prophylaxis in patients
undergoing biliary tract surgery. (c) 2006 Published by Elsevier B.V.
and the International Society of Chemotherapy.
Συγγραφείς:
Petrikkos, G
Kastanakis, M
Markogiannakis, A
Kastanakis, S
and Bastounis, E
Antonios, P
Daikos, GL
Katsilambros, N
Περιοδικό:
International Journal of Antimicrobial Agents
Εκδότης:
ELSEVIER SCIENCE BV
Λέξεις-κλειδιά:
pharmacokinetics; cefepime; bile; gall bladder tissue.; prophylaxis
DOI:
10.1016/j.ijantimicag.2005.11.007
