Τίτλος:
Prolonged occupational exposure leads to allergic airway sensitization and chronic airway and systemic inflammation in professional firefighters
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and objectives Little data exist on short- and long-term effects of occupational exposure on airway and systemic inflammation in professional firefighters. We aimed to characterize airway and systemic inflammation in training firefighters with a maximum occupational exposure of 1 year compared to the long-term exposure of professional firefighters. Methods A questionnaire for symptoms and exposure, pulmonary function, atopy, bronchial hyper-responsiveness, and markers of inflammation in induced sputum, serum, bronchoalveolar lavage (BAL) fluid and bronchial biopsies were assessed in a total of 92 firefighters (63 full-time professionals and 29 trainees). Results Professional firefighters showed allergic bronchial sensitization documented by the presence of atopy, and eosinophilia in induced sputum, BAL and bronchial biopsies. IL-8, ECP, VEGF, and TNF-α levels were statistically significantly higher in the sputum supernatants of professional firefighters compared to the trainees (p = 0.04, p = 0.02, p = 0.04, and p = 0.02, respectively). Serum IL-8 and TNF-α levels were also statistically significantly higher in the group of professional firefighters (p = 0.04, p = 0.03, respectively). Finally, there was a linear correlation between the duration of the occupation in Service and the degree of airway and systemic inflammation. Conclusions These results indicate a “dose-response” effect of chronic exposure to a polluted environment on bronchial and systemic inflammation in professional firefighters. © 2016 Elsevier Ltd
Συγγραφείς:
Gianniou, N.
Katsaounou, P.
Dima, E.
Giannakopoulou, C.-E.
Kardara, M.
Saltagianni, V.
Trigidou, R.
Kokkini, A.
Bakakos, P.
Markozannes, E.
Litsiou, E.
Tsakatikas, A.
Papadopoulos, C.
Roussos, C.
Koulouris, N.
Rovina, N.
Περιοδικό:
Advances in Respiratory Medicine
Εκδότης:
W.B. Saunders Ltd
Λέξεις-κλειδιά:
eosinophil cationic protein; interleukin 13; interleukin 4; interleukin 8; tumor necrosis factor alpha; vasculotropin; eosinophil cationic protein; interleukin 8; tumor necrosis factor; vasculotropin A, adult; allergic airway inflammation; allergic rhinitis; Article; atopy; bronchoscopy; bronchus biopsy; chest tightness; chronic bronchitis; controlled study; coughing; dyspnea; fire fighter; forced expiratory volume; forced vital capacity; histopathology; human; human tissue; long term exposure; lung function; lung lavage; major clinical study; male; occupational exposure; prick test; priority journal; respiratory tract allergy; sensitization; serum; skin test; sneezing; sputum; wheezing; blood; bronchoalveolar lavage fluid; bronchus hyperreactivity; eosinophil; hypersensitivity; immunology; inflammation; inhalation test; lung function test; metabolism; occupational exposure; pathology; pathophysiology; procedures; respiratory system; systemic inflammatory response syndrome, Adult; Bronchial Hyperreactivity; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Eosinophil Cationic Protein; Eosinophils; Firefighters; Humans; Hypersensitivity; Inflammation; Interleukin-8; Male; Occupational Exposure; Respiratory Function Tests; Respiratory System; Sputum; Systemic Inflammatory Response Syndrome; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A
DOI:
10.1016/j.rmed.2016.07.006
