Τίτλος:
A toddler diagnosed with severe postinfectious bronchiolitis obliterans and COVID-19 infection
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
During the COVID-19 pandemic, management of SARS-CoV-2 infection in children with underlying chronic lung disease has been challenging. There are limited studies in children with respiratory comorbidities, apart from asthma, presumably due to low morbidity of SARS-CoV-2 infection in the general pediatric population along with the low incidence of certain pulmonary conditions. Compassionate use of remdesivir has been shown to reduce time to clinical improvement in adults and has been retrospectively studied in small pediatric cohorts with promising results. Whether children with underlying respiratory conditions may benefit from antiviral treatment in the context of different pathophysiologic backgrounds and unknown drug safety and efficacy needs to be further evaluated. We present a case of COVID-19 infection in a 3-year old toddler with severe postinfectious bronchiolitis obliterans, who received compassionate treatment with 5-day-course of remdesivir, and recovered with favourable outcome. © 2021 Wiley Periodicals LLC
Συγγραφείς:
Koletsi, P.
Antoniadi, M.
Mermiri, D.
Koltsida, G.
Koukou, D.
Noni, M.
Spoulou, V.
Michos, A.
Περιοδικό:
Pediatric Pulmonology
Εκδότης:
John Wiley and Sons Inc
Λέξεις-κλειδιά:
antibiotic agent; azithromycin; dexamethasone; fluticasone; methylprednisolone; montelukast; oxygen; remdesivir; salbutamol; adenosine phosphate; alanine; antivirus agent, bronchiectasis; bronchiolitis obliterans; case report; child; clinical article; clinical outcome; coronavirus disease 2019; disease severity; drug response; follow up; ground glass opacity; high resolution computer tomography; hospitalization; human; human cell; invasive ventilation; laboratory test; length of stay; Letter; loading drug dose; low drug dose; maintenance drug dose; male; medical history; nasopharyngeal swab; nonhuman; noninvasive ventilation; oxygen therapy; preschool child; thorax radiography; treatment duration; adult; complication; pandemic; retrospective study, Adenosine Monophosphate; Adult; Alanine; Antiviral Agents; Bronchiolitis Obliterans; Child; Child, Preschool; COVID-19; Humans; Pandemics; Retrospective Studies; SARS-CoV-2
