Τίτλος:
The interplay of KRAS mutational status with tumor laterality in non-metastatic colorectal cancer: An international, multi-institutional study in patients with known KRAS, BRAF, and MSI status
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Although the prognostic relevance of KRAS status in metastatic colorectal cancer (CRC) depends on tumor laterality, this relationship is largely unknown in non-metastatic CRC. Methods: Patients who underwent resection for non-metastatic CRC between 2000 and 2018 were identified from institutional databases at six academic tertiary centers in Europe and Japan. The prognostic relevance of KRAS status in patients with right-sided (RS), left-sided (LS), and rectal cancers was assessed. Results: Of the 1093 eligible patients, 378 had right-sided tumors and 715 had left-sided tumors. Among patients with RS tumors, the 5-year overall (OS) and recurrence-free survival (RFS) for patients with KRASmut versus wild-type tumors was not shown to differ significantly (82.2% vs. 83.2% and 72.1% vs. 76.7%, respectively, all p >.05). Among those with LS tumors, KRAS mutation was associated with shorter 5-year OS and RFS on both the univariable (OS: 79.4% vs. 86.1%, p =.004; RFS: 68.8% vs. 77.3%, p =.005) and multivariable analysis (OS: HR: 1.52, p =.019; RFS: HR: 1.32, p =.05). Conclusions: KRAS mutation status was independently prognostic among patients with LS tumors, but this association failed to reach statistical significance in RS and rectal tumors. These findings confirm reports in metastatic CRC and underline the possible biologic importance of tumor location. © 2020 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC
Συγγραφείς:
Kamphues, C.
Kadowaki, S.
Amini, N.
van den Berg, I.
Wang, J.
Andreatos, N.
Sakamoto, Y.
Ogura, T.
Kakuta, M.
Pikouli, A.
Geka, D.
Daitoku, N.
Theochari, M.
Buettner, S.
Akiyama, T.
Antoniou, E.
Pikoulis, E.
Theodoropoulos, G.
Imai, K.
Ijzermans, J.N.M.
Margonis, G.A.
Akagi, K.
Kreis, M.E.
Περιοδικό:
International Journal of Surgical Oncology
Εκδότης:
John Wiley and Sons Inc
Λέξεις-κλειδιά:
B Raf kinase; capecitabine; fluorouracil; K ras protein; oxaliplatin; B Raf kinase; BRAF protein, human; KRAS protein, human; microsatellite DNA; protein p21; tumor marker, adjuvant chemotherapy; adult; aged; Article; cancer localization; cancer prognosis; cancer staging; cancer surgery; cancer survival; colorectal cancer; controlled study; Europe; female; gene mutation; human; Japan; lymph vessel metastasis; major clinical study; male; microsatellite instability; multicenter study; oncogene K ras; overall survival; priority journal; recurrence free survival; statistical significance; clinical trial; colorectal surgery; colorectal tumor; follow up; genetics; liver tumor; middle aged; mortality; mutation; pathology; prognosis; retrospective study; survival rate; tumor recurrence, Aged; Biomarkers, Tumor; Colorectal Neoplasms; Colorectal Surgery; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Microsatellite Repeats; Middle Aged; Mutation; Neoplasm Recurrence, Local; Prognosis; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Retrospective Studies; Survival Rate
