Περίληψη:
Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants’ shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e−09) and 0.77 (0.72, 0.82; ptrend = 1.7e−15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e−04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence. © 2019, Springer Nature B.V.
Συγγραφείς:
Naudin, S.
Viallon, V.
Hashim, D.
Freisling, H.
Jenab, M.
Weiderpass, E.
Perrier, F.
McKenzie, F.
Bueno-de-Mesquita, H.B.
Olsen, A.
Tjønneland, A.
Dahm, C.C.
Overvad, K.
Mancini, F.R.
Rebours, V.
Boutron-Ruault, M.-C.
Katzke, V.
Kaaks, R.
Bergmann, M.
Boeing, H.
Peppa, E.
Karakatsani, A.
Trichopoulou, A.
Pala, V.
Masala, G.
Panico, S.
Tumino, R.
Sacerdote, C.
May, A.M.
van Gils, C.H.
Rylander, C.
Borch, K.B.
Chirlaque López, M.D.
Sánchez, M.-J.
Ardanaz, E.
Quirós, J.R.
Amiano Exezarreta, P.
Sund, M.
Drake, I.
Regnér, S.
Travis, R.C.
Wareham, N.
Aune, D.
Riboli, E.
Gunter, M.J.
Duell, E.J.
Brennan, P.
Ferrari, P.
Λέξεις-κλειδιά:
adult; age; alcohol consumption; Article; body mass; cancer incidence; cancer risk; cohort analysis; dietary exposure; dietary intake; female; follow up; healthy lifestyle; healthy lifestyle index; human; major clinical study; male; obesity; pancreas cancer; people by smoking status; physical activity; population; prospective study; risk assessment; scoring system; waist hip ratio; abdominal obesity; complication; drinking behavior; exercise; incidence; nutritional status; pancreas tumor; proportional hazards model; risk factor; smoking, Alcohol Drinking; Cohort Studies; Exercise; Female; Healthy Lifestyle; Humans; Incidence; Male; Nutritional Status; Obesity; Obesity, Abdominal; Pancreatic Neoplasms; Proportional Hazards Models; Prospective Studies; Risk Factors; Smoking; Waist-Hip Ratio
