Περίληψη:
Objective: Colchicine has been utilized safely in a variety of cardiovascular clinical conditions. Among its potential mechanisms of action is the non-selective inhibition of NLRP3 inflammasome which is thought to be a major pathophysiologic component in the clinical course of patients with COVID-19. GRECCO-19 will be a prospective, randomized, open-labeled, controlled study to assess the effects of colchicine in COVID-19 complications prevention. Methods: Patients with laboratory confirmed SARS-CoV-2 infection (under RT PCR) and clinical picture that involves temperature >37.5 oC and at least two out of the: i. sustained coughing, ii. sustained throat pain, iii. Anosmia and/or ageusia, iv. fatigue/tiredness, v. PaO2<95 mmHg will be included. Patients will be randomised (1:1) in colchicine or control group. Results: Trial results will be disseminated through peer-reviewed publications and conference presentations. Conclusion: GRECCO-19 trial aims to identify whether colchicine may positively intervene in the clinical course of COVID-19. (ClinicalTrials.gov Identifier: NCT04326790). © 2020 Hellenic Society of Cardiology
Συγγραφείς:
Deftereos, S.G.
Siasos, G.
Giannopoulos, G.
Vrachatis, D.A.
Angelidis, C.
Giotaki, S.G.
Gargalianos, P.
Giamarellou, H.
Gogos, C.
Daikos, G.
Lazanas, M.
Lagiou, P.
Saroglou, G.
Sipsas, N.
Tsiodras, S.
Chatzigeorgiou, D.
Moussas, N.
Kotanidou, A.
Koulouris, N.
Oikonomou, E.
Kaoukis, A.
Kossyvakis, C.
Raisakis, K.
Fountoulaki, K.
Comis, M.
Tsiachris, D.
Sarri, E.
Theodorakis, A.
Martinez-Dolz, L.
Sanz-Sánchez, J.
Reimers, B.
Stefanini, G.G.
Cleman, M.
Filippou, D.
Olympios, C.D.
Pyrgakis, V.N.
Goudevenos, J.
Hahalis, G.
Kolettis, T.M.
Iliodromitis, E.
Tousoulis, D.
Stefanadis, C.
Λέξεις-κλειδιά:
azithromycin; C reactive protein; colchicine; troponin; antirheumatic agent; colchicine; troponin, ageusia; anosmia; Article; artificial ventilation; blood oxygen tension; clinical trial; controlled study; coronavirus disease 2019; coughing; fatigue; human; loading drug dose; lung function test; mortality; open study; prospective study; randomized controlled trial; reverse transcription polymerase chain reaction; sore throat; Betacoronavirus; blood; complication; Coronavirus infection; heart disease; isolation and purification; laboratory technique; pandemic; pathophysiology; procedures; randomized controlled trial (topic); symptom assessment; virus pneumonia, Antirheumatic Agents; Betacoronavirus; Clinical Laboratory Techniques; Colchicine; Coronavirus Infections; Heart Diseases; Humans; Pandemics; Pneumonia, Viral; Randomized Controlled Trials as Topic; Symptom Assessment; Troponin
