Τίτλος:
Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: PGC-1α is already known as a significant regulator of mitochondrial biogenesis, oxidative phosphorylation and fatty acid metabolism. Our study focuses on the role of PGC1α in morbid obesity, in five different tissues, collected from 50 severely obese patients during planned bariatric surgery. Methods: The investigated tissues included subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), skeletal muscle (SM), extramyocellular adipose tissue (EMAT) and liver. PGC1α expression was investigated with immunohistochemistry and evaluated with microscopy. Results: Our findings highlighted significant positive inter-tissue correlations regarding PGC-1α expression between several tissue pairs (VAT-SAT, VAT-SM, VAT-EMAT, SAT-SM, SAT-EMAT, SM-EMAT). Moreover, we found significant negative correlations between PGC1α expression in VAT with CD68 expression in skeletal muscle and EMAT, implying a possible protective role of PGC1α against obesity-induced inflammation. Conclusion: Unmasking the inter-tissue communication networks regarding PGC-1α expression in morbid obesity, will give more insight into its significant role in obesity-induced diseases. PGC1α could potentially represent a future preventive and therapeutic target against obesity-induced disease, probably through enhancing mitochondrial biogenesis and metabolism. © 2018 Hellenic Society of Cardiology
Συγγραφείς:
Balampanis, K.
Chasapi, A.
Kourea, E.
Tanoglidi, A.
Hatziagelaki, E.
Lambadiari, V.
Dimitriadis, G.
Lambrou, G.I.
Kalfarentzos, F.
Melachrinou, M.
Sotiropoulou-Bonikou, G.
Περιοδικό:
Ελληνική καρδιολογική επιθεώρηση
Εκδότης:
Hellenic Cardiological Society
Λέξεις-κλειδιά:
alanine aminotransferase; CD3 antibody; CD68 antigen; cholesterol; fatty acid; glucose; high density lipoprotein cholesterol; low density lipoprotein; low density lipoprotein cholesterol; peroxisome proliferator activated receptor gamma coactivator 1alpha; triacylglycerol; biological marker; CD68 antigen, human; differentiation antigen; fatty acid; leukocyte antigen; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor gamma coactivator 1alpha; PPARGC1A protein, human, adult; alcohol consumption; Article; body mass; diabetes mellitus; fatty acid metabolism; female; gene expression; glucose blood level; histopathology; human; human tissue; hypertension; immunohistochemistry; inflammation; intra-abdominal fat; intraperitoneal fat; lipid storage; liver biopsy; liver fibrosis; male; metabolic syndrome X; mitochondrial biogenesis; obesity; oxidative stress; power analysis; protein expression; real time polymerase chain reaction; Roux-en-Y gastric bypass; scoring system; sedentary lifestyle; skeletal muscle; subcutaneous fat; adipose tissue; bariatric surgery; complication; diabetes mellitus; metabolic syndrome X; metabolism; middle aged; mitochondrion; morbid obesity; oxidative phosphorylation; procedures; ultrastructure, Adipose Tissue; Adult; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bariatric Surgery; Biomarkers; Diabetes Mellitus; Fatty Acids; Female; Humans; Immunohistochemistry; Inflammation; Intra-Abdominal Fat; Male; Metabolic Syndrome; Middle Aged; Mitochondria; Muscle, Skeletal; Obesity, Morbid; Oxidative Phosphorylation; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Peroxisome Proliferator-Activated Receptors
DOI:
10.1016/j.hjc.2018.08.002
