Τίτλος:
HDL cholesterol levels and endothelial glycocalyx integrity in treated hypertensive patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Endothelial dysfunction indicates target organ damage in hypertensive patients. The integrity of endothelial glycocalyx (EG) plays a vital role in vascular permeability, inflammation and elasticity, and finally to cardiovascular disease. The authors aimed to investigate the role of increased HDL cholesterol (HDL-C) levels, which usually are considered protective against cardiovascular disease, in EG integrity in older hypertensive patients. The authors studied 120 treated hypertensive patients older than 50 years were divided regarding HDL-C tertiles in group HDLH (HDL-C ≥ 71 mg/dL, upper HDL-C tertile) and group HDLL (HDL-C < 71 mg/dL, two lower HDL-C tertiles). Increased perfusion boundary region (PBR) of the sublingual arterial microvessels (ranging from 5 to 9 µm) using Sideview Darkfield imaging (Microscan, Glycocheck) was measured as a non-invasive accurate index of reduced EG thickness. PBR 5-9 was significantly decreased in group HDLH (P = 0.04). In the whole population, HDL-C was inversely but moderately related to PBR 5-9 (r = −0.22, P = 0.01). In a multiple linear regression analysis model, using age, BMI, smoking habit, HDL-C, LDL-C, and office SBP, as independent variables, the authors found that BMI (β = 0.25, P = 0.006) independently predicted PBR 5-9 in the whole population. In older hypertensive patients, HDL-C ranging between 71 and 101 mg/dL might moderately protect EG and subsequently endothelial function. Future studies in several groups of low- or high-risk hypertensives are needed in order to evaluate the beneficial role of extremely elevated HDL-C regarding cardiovascular risk evaluation as well as endothelial glycocalyx as a novel index of target organ damage in essential hypertension. ©2018 Wiley Periodicals, Inc.
Συγγραφείς:
Triantafyllidi, H.
Benas, D.
Vlachos, S.
Vlastos, D.
Pavlidis, G.
Schoinas, A.
Varoudi, M.
Birmpa, D.
Moutsatsou, P.
Lekakis, J.
Ikonomidis, I.
Περιοδικό:
The Journal of Clinical Hypertension
Εκδότης:
Blackwell Publishing Inc.
Λέξεις-κλειδιά:
high density lipoprotein cholesterol, aged; arterial stiffness; blood; blood pressure measurement; cardiovascular disease; complication; cross-sectional study; devices; female; glycocalyx; human; hypertension; male; metabolism; middle aged; pathology; physiology; procedures; pulse wave; risk factor; smoking; vascular endothelium, Aged; Blood Pressure Determination; Cardiovascular Diseases; Cholesterol, HDL; Cross-Sectional Studies; Endothelium, Vascular; Female; Glycocalyx; Humans; Hypertension; Male; Middle Aged; Pulse Wave Analysis; Risk Factors; Smoking; Vascular Stiffness
